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Associative responses to visual shape stimuli in the mouse auditory cortex
Humans can recall various aspects of a characteristic sound as a whole when they see a visual shape stimulus that has been intimately associated with the sound. In subjects with audio-visual associative memory, auditory responses that code the associated sound may be induced in the auditory cortex i...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6776301/ https://www.ncbi.nlm.nih.gov/pubmed/31581242 http://dx.doi.org/10.1371/journal.pone.0223242 |
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author | Ogi, Manabu Yamagishi, Tatsuya Tsukano, Hiroaki Nishio, Nana Hishida, Ryuichi Takahashi, Kuniyuki Horii, Arata Shibuki, Katsuei |
author_facet | Ogi, Manabu Yamagishi, Tatsuya Tsukano, Hiroaki Nishio, Nana Hishida, Ryuichi Takahashi, Kuniyuki Horii, Arata Shibuki, Katsuei |
author_sort | Ogi, Manabu |
collection | PubMed |
description | Humans can recall various aspects of a characteristic sound as a whole when they see a visual shape stimulus that has been intimately associated with the sound. In subjects with audio-visual associative memory, auditory responses that code the associated sound may be induced in the auditory cortex in response to presentation of the associated visual shape stimulus. To test this possibility, mice were pre-exposed to a combination of an artificial sound mimicking a cat’s “meow” and a visual shape stimulus of concentric circles or stars for more than two weeks, since such passive exposure is known to be sufficient for inducing audio-visual associative memory in mice. After the exposure, we anesthetized the mice, and presented them with the associated visual shape stimulus. We found that associative responses in the auditory cortex were induced in response to the visual stimulus. The associative auditory responses were observed when complex sounds such as “meow” were used for formation of audio-visual associative memory, but not when a pure tone was used. These results suggest that associative auditory responses in the auditory cortex represent the characteristics of the complex sound stimulus as a whole. |
format | Online Article Text |
id | pubmed-6776301 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-67763012019-10-12 Associative responses to visual shape stimuli in the mouse auditory cortex Ogi, Manabu Yamagishi, Tatsuya Tsukano, Hiroaki Nishio, Nana Hishida, Ryuichi Takahashi, Kuniyuki Horii, Arata Shibuki, Katsuei PLoS One Research Article Humans can recall various aspects of a characteristic sound as a whole when they see a visual shape stimulus that has been intimately associated with the sound. In subjects with audio-visual associative memory, auditory responses that code the associated sound may be induced in the auditory cortex in response to presentation of the associated visual shape stimulus. To test this possibility, mice were pre-exposed to a combination of an artificial sound mimicking a cat’s “meow” and a visual shape stimulus of concentric circles or stars for more than two weeks, since such passive exposure is known to be sufficient for inducing audio-visual associative memory in mice. After the exposure, we anesthetized the mice, and presented them with the associated visual shape stimulus. We found that associative responses in the auditory cortex were induced in response to the visual stimulus. The associative auditory responses were observed when complex sounds such as “meow” were used for formation of audio-visual associative memory, but not when a pure tone was used. These results suggest that associative auditory responses in the auditory cortex represent the characteristics of the complex sound stimulus as a whole. Public Library of Science 2019-10-03 /pmc/articles/PMC6776301/ /pubmed/31581242 http://dx.doi.org/10.1371/journal.pone.0223242 Text en © 2019 Ogi et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Ogi, Manabu Yamagishi, Tatsuya Tsukano, Hiroaki Nishio, Nana Hishida, Ryuichi Takahashi, Kuniyuki Horii, Arata Shibuki, Katsuei Associative responses to visual shape stimuli in the mouse auditory cortex |
title | Associative responses to visual shape stimuli in the mouse auditory cortex |
title_full | Associative responses to visual shape stimuli in the mouse auditory cortex |
title_fullStr | Associative responses to visual shape stimuli in the mouse auditory cortex |
title_full_unstemmed | Associative responses to visual shape stimuli in the mouse auditory cortex |
title_short | Associative responses to visual shape stimuli in the mouse auditory cortex |
title_sort | associative responses to visual shape stimuli in the mouse auditory cortex |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6776301/ https://www.ncbi.nlm.nih.gov/pubmed/31581242 http://dx.doi.org/10.1371/journal.pone.0223242 |
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