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Associative responses to visual shape stimuli in the mouse auditory cortex

Humans can recall various aspects of a characteristic sound as a whole when they see a visual shape stimulus that has been intimately associated with the sound. In subjects with audio-visual associative memory, auditory responses that code the associated sound may be induced in the auditory cortex i...

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Autores principales: Ogi, Manabu, Yamagishi, Tatsuya, Tsukano, Hiroaki, Nishio, Nana, Hishida, Ryuichi, Takahashi, Kuniyuki, Horii, Arata, Shibuki, Katsuei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6776301/
https://www.ncbi.nlm.nih.gov/pubmed/31581242
http://dx.doi.org/10.1371/journal.pone.0223242
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author Ogi, Manabu
Yamagishi, Tatsuya
Tsukano, Hiroaki
Nishio, Nana
Hishida, Ryuichi
Takahashi, Kuniyuki
Horii, Arata
Shibuki, Katsuei
author_facet Ogi, Manabu
Yamagishi, Tatsuya
Tsukano, Hiroaki
Nishio, Nana
Hishida, Ryuichi
Takahashi, Kuniyuki
Horii, Arata
Shibuki, Katsuei
author_sort Ogi, Manabu
collection PubMed
description Humans can recall various aspects of a characteristic sound as a whole when they see a visual shape stimulus that has been intimately associated with the sound. In subjects with audio-visual associative memory, auditory responses that code the associated sound may be induced in the auditory cortex in response to presentation of the associated visual shape stimulus. To test this possibility, mice were pre-exposed to a combination of an artificial sound mimicking a cat’s “meow” and a visual shape stimulus of concentric circles or stars for more than two weeks, since such passive exposure is known to be sufficient for inducing audio-visual associative memory in mice. After the exposure, we anesthetized the mice, and presented them with the associated visual shape stimulus. We found that associative responses in the auditory cortex were induced in response to the visual stimulus. The associative auditory responses were observed when complex sounds such as “meow” were used for formation of audio-visual associative memory, but not when a pure tone was used. These results suggest that associative auditory responses in the auditory cortex represent the characteristics of the complex sound stimulus as a whole.
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spelling pubmed-67763012019-10-12 Associative responses to visual shape stimuli in the mouse auditory cortex Ogi, Manabu Yamagishi, Tatsuya Tsukano, Hiroaki Nishio, Nana Hishida, Ryuichi Takahashi, Kuniyuki Horii, Arata Shibuki, Katsuei PLoS One Research Article Humans can recall various aspects of a characteristic sound as a whole when they see a visual shape stimulus that has been intimately associated with the sound. In subjects with audio-visual associative memory, auditory responses that code the associated sound may be induced in the auditory cortex in response to presentation of the associated visual shape stimulus. To test this possibility, mice were pre-exposed to a combination of an artificial sound mimicking a cat’s “meow” and a visual shape stimulus of concentric circles or stars for more than two weeks, since such passive exposure is known to be sufficient for inducing audio-visual associative memory in mice. After the exposure, we anesthetized the mice, and presented them with the associated visual shape stimulus. We found that associative responses in the auditory cortex were induced in response to the visual stimulus. The associative auditory responses were observed when complex sounds such as “meow” were used for formation of audio-visual associative memory, but not when a pure tone was used. These results suggest that associative auditory responses in the auditory cortex represent the characteristics of the complex sound stimulus as a whole. Public Library of Science 2019-10-03 /pmc/articles/PMC6776301/ /pubmed/31581242 http://dx.doi.org/10.1371/journal.pone.0223242 Text en © 2019 Ogi et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Ogi, Manabu
Yamagishi, Tatsuya
Tsukano, Hiroaki
Nishio, Nana
Hishida, Ryuichi
Takahashi, Kuniyuki
Horii, Arata
Shibuki, Katsuei
Associative responses to visual shape stimuli in the mouse auditory cortex
title Associative responses to visual shape stimuli in the mouse auditory cortex
title_full Associative responses to visual shape stimuli in the mouse auditory cortex
title_fullStr Associative responses to visual shape stimuli in the mouse auditory cortex
title_full_unstemmed Associative responses to visual shape stimuli in the mouse auditory cortex
title_short Associative responses to visual shape stimuli in the mouse auditory cortex
title_sort associative responses to visual shape stimuli in the mouse auditory cortex
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6776301/
https://www.ncbi.nlm.nih.gov/pubmed/31581242
http://dx.doi.org/10.1371/journal.pone.0223242
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