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Impact evaluation of Zika epidemic on congenital anomalies registration in Brazil: An interrupted time series analysis

This study aimed to assess the impact of the Zika epidemic on the registration of birth defects in Brazil. We used an interrupted time series analysis design to identify changes in the trends in the registration of congenital anomalies. We obtained monthly data from Brazilian Live Birth Information...

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Autores principales: Paixão, Enny S., Rodrigues, Moreno S., Cardim, Luciana L., Oliveira, Juliane F., L. C., Catharina, Costa, Maria da Conceição N., Barreto, Maurício L., Rodrigues, Laura C., Smeeth, Liam, Andrade, Roberto F. S., Oliveira, Wanderson K., Teixeira, Maria Glória
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6776346/
https://www.ncbi.nlm.nih.gov/pubmed/31545803
http://dx.doi.org/10.1371/journal.pntd.0007721
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author Paixão, Enny S.
Rodrigues, Moreno S.
Cardim, Luciana L.
Oliveira, Juliane F.
L. C., Catharina
Costa, Maria da Conceição N.
Barreto, Maurício L.
Rodrigues, Laura C.
Smeeth, Liam
Andrade, Roberto F. S.
Oliveira, Wanderson K.
Teixeira, Maria Glória
author_facet Paixão, Enny S.
Rodrigues, Moreno S.
Cardim, Luciana L.
Oliveira, Juliane F.
L. C., Catharina
Costa, Maria da Conceição N.
Barreto, Maurício L.
Rodrigues, Laura C.
Smeeth, Liam
Andrade, Roberto F. S.
Oliveira, Wanderson K.
Teixeira, Maria Glória
author_sort Paixão, Enny S.
collection PubMed
description This study aimed to assess the impact of the Zika epidemic on the registration of birth defects in Brazil. We used an interrupted time series analysis design to identify changes in the trends in the registration of congenital anomalies. We obtained monthly data from Brazilian Live Birth Information System and used two outcome definitions: 1) rate of congenital malformation of the brain and eye (likely to be affected by Zika and its complications) 2) rate of congenital malformation not related to the brain or eye unlikely to be causally affected by Zika. The period between maternal infection with Zika and diagnosis of congenital abnormality attributable to the infection is around six months. We therefore used September 2015 as the interruption point in the time series, six months following March 2015 when cases of Zika started to increase. For the purposes of this analysis, we considered the period from January 2010 to September 2015 to be “pre-Zika event,” and the period from just after September 2015 to December 2017 to be “post-Zika event.” We found that immediately after the interruption point, there was a great increase in the notification rate of congenital anomalies of 14.9/10,000 live births in the brain and eye group and of 5.2/10,000 live births in the group not related with brain or eye malformations. This increase in reporting was in all regions of the country (except in the South) and especially in the Northeast. In the period “post-Zika event”, unlike the brain and eye group which showed a monthly decrease, the group without brain or eye malformations showed a slow but significant increase (relative to the pre-Zika trend) of 0.2/10,000 live births. These findings suggest an overall improvement in the registration of birth malformations, including malformations that were not attributed to Zika, during and after the Zika epidemic.
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spelling pubmed-67763462019-10-11 Impact evaluation of Zika epidemic on congenital anomalies registration in Brazil: An interrupted time series analysis Paixão, Enny S. Rodrigues, Moreno S. Cardim, Luciana L. Oliveira, Juliane F. L. C., Catharina Costa, Maria da Conceição N. Barreto, Maurício L. Rodrigues, Laura C. Smeeth, Liam Andrade, Roberto F. S. Oliveira, Wanderson K. Teixeira, Maria Glória PLoS Negl Trop Dis Research Article This study aimed to assess the impact of the Zika epidemic on the registration of birth defects in Brazil. We used an interrupted time series analysis design to identify changes in the trends in the registration of congenital anomalies. We obtained monthly data from Brazilian Live Birth Information System and used two outcome definitions: 1) rate of congenital malformation of the brain and eye (likely to be affected by Zika and its complications) 2) rate of congenital malformation not related to the brain or eye unlikely to be causally affected by Zika. The period between maternal infection with Zika and diagnosis of congenital abnormality attributable to the infection is around six months. We therefore used September 2015 as the interruption point in the time series, six months following March 2015 when cases of Zika started to increase. For the purposes of this analysis, we considered the period from January 2010 to September 2015 to be “pre-Zika event,” and the period from just after September 2015 to December 2017 to be “post-Zika event.” We found that immediately after the interruption point, there was a great increase in the notification rate of congenital anomalies of 14.9/10,000 live births in the brain and eye group and of 5.2/10,000 live births in the group not related with brain or eye malformations. This increase in reporting was in all regions of the country (except in the South) and especially in the Northeast. In the period “post-Zika event”, unlike the brain and eye group which showed a monthly decrease, the group without brain or eye malformations showed a slow but significant increase (relative to the pre-Zika trend) of 0.2/10,000 live births. These findings suggest an overall improvement in the registration of birth malformations, including malformations that were not attributed to Zika, during and after the Zika epidemic. Public Library of Science 2019-09-23 /pmc/articles/PMC6776346/ /pubmed/31545803 http://dx.doi.org/10.1371/journal.pntd.0007721 Text en © 2019 Paixão et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Paixão, Enny S.
Rodrigues, Moreno S.
Cardim, Luciana L.
Oliveira, Juliane F.
L. C., Catharina
Costa, Maria da Conceição N.
Barreto, Maurício L.
Rodrigues, Laura C.
Smeeth, Liam
Andrade, Roberto F. S.
Oliveira, Wanderson K.
Teixeira, Maria Glória
Impact evaluation of Zika epidemic on congenital anomalies registration in Brazil: An interrupted time series analysis
title Impact evaluation of Zika epidemic on congenital anomalies registration in Brazil: An interrupted time series analysis
title_full Impact evaluation of Zika epidemic on congenital anomalies registration in Brazil: An interrupted time series analysis
title_fullStr Impact evaluation of Zika epidemic on congenital anomalies registration in Brazil: An interrupted time series analysis
title_full_unstemmed Impact evaluation of Zika epidemic on congenital anomalies registration in Brazil: An interrupted time series analysis
title_short Impact evaluation of Zika epidemic on congenital anomalies registration in Brazil: An interrupted time series analysis
title_sort impact evaluation of zika epidemic on congenital anomalies registration in brazil: an interrupted time series analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6776346/
https://www.ncbi.nlm.nih.gov/pubmed/31545803
http://dx.doi.org/10.1371/journal.pntd.0007721
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