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Neddylation inhibitor MLN4924 suppresses cilia formation by modulating AKT1

The primary cilium is a microtubule-based sensory organelle. The molecular mechanism that regulates ciliary dynamics remains elusive. Here, we report an unexpected finding that MLN4924, a small molecule inhibitor of NEDD8-activating enzyme (NAE), blocks primary ciliary formation by inhibiting synthe...

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Detalles Bibliográficos
Autores principales:	Mao, Hongmei, Tang, Zaiming, Li, Hua, Sun, Bo, Tan, Mingjia, Fan, Shaohua, Zhu, Yuan, Sun, Yi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Higher Education Press 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6776484/ https://www.ncbi.nlm.nih.gov/pubmed/30850948 http://dx.doi.org/10.1007/s13238-019-0614-3

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