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Verteporfin-induced lysosomal compartment dysregulation potentiates the effect of sorafenib in hepatocellular carcinoma

Lysosomal sequestration of anti-cancer compounds reduces drug availability at intracellular target sites, thereby limiting drug-sensitivity and inducing chemoresistance. For hepatocellular carcinoma (HCC), sorafenib (SF) is the first line systemic treatment, as well as a simultaneous activator of au...

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Detalles Bibliográficos
Autores principales:	Gavini, Jacopo, Dommann, Noëlle, Jakob, Manuel O., Keogh, Adrian, Bouchez, Laure C., Karkampouna, Sofia, Julio, Marianna Kruithof-de, Medova, Michaela, Zimmer, Yitzhak, Schläfli, Anna M., Tschan, Mario P., Candinas, Daniel, Stroka, Deborah, Banz, Vanessa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6776510/ https://www.ncbi.nlm.nih.gov/pubmed/31582741 http://dx.doi.org/10.1038/s41419-019-1989-z

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