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Verteporfin-induced lysosomal compartment dysregulation potentiates the effect of sorafenib in hepatocellular carcinoma
Lysosomal sequestration of anti-cancer compounds reduces drug availability at intracellular target sites, thereby limiting drug-sensitivity and inducing chemoresistance. For hepatocellular carcinoma (HCC), sorafenib (SF) is the first line systemic treatment, as well as a simultaneous activator of au...
Autores principales: | Gavini, Jacopo, Dommann, Noëlle, Jakob, Manuel O., Keogh, Adrian, Bouchez, Laure C., Karkampouna, Sofia, Julio, Marianna Kruithof-de, Medova, Michaela, Zimmer, Yitzhak, Schläfli, Anna M., Tschan, Mario P., Candinas, Daniel, Stroka, Deborah, Banz, Vanessa |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6776510/ https://www.ncbi.nlm.nih.gov/pubmed/31582741 http://dx.doi.org/10.1038/s41419-019-1989-z |
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