C9-ALS/FTD-linked proline–arginine dipeptide repeat protein associates with paraspeckle components and increases paraspeckle formation

A GGGGCC hexanucleotide repeat expansion in the C9ORF72 gene has been identified as the most common genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia. The repeat expansion undergoes unconventional translation to produce five dipeptide repeat proteins (DPRs). Although DPRs ar...

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Detalles Bibliográficos
Autores principales: Suzuki, Hiroaki, Shibagaki, Yoshio, Hattori, Seisuke, Matsuoka, Masaaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6776546/
https://www.ncbi.nlm.nih.gov/pubmed/31582731
http://dx.doi.org/10.1038/s41419-019-1983-5

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