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SR9009 administered for one day after myocardial ischemia-reperfusion prevents heart failure in mice by targeting the cardiac inflammasome

Reperfusion of patients after myocardial infarction (heart attack) triggers cardiac inflammation that leads to infarct expansion and heart failure (HF). We previously showed that the circadian mechanism is a critical regulator of reperfusion injury. However, whether pharmacological targeting using c...

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Detalles Bibliográficos
Autores principales: Reitz, Cristine J., Alibhai, Faisal J., Khatua, Tarak N., Rasouli, Mina, Bridle, Byram W., Burris, Thomas P., Martino, Tami A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6776554/
https://www.ncbi.nlm.nih.gov/pubmed/31602405
http://dx.doi.org/10.1038/s42003-019-0595-z