Complement Inhibitors in Clinical Trials for Glomerular Diseases

Defective complement action is a cause of several human glomerular diseases including atypical hemolytic uremic syndrome (aHUS), anti-neutrophil cytoplasmic antibody mediated vasculitis (ANCA), C3 glomerulopathy, IgA nephropathy, immune complex membranoproliferative glomerulonephritis, ischemic repe...

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Autores principales: Zipfel, Peter F., Wiech, Thorsten, Rudnick, Ramona, Afonso, Sara, Person, Fermin, Skerka, Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6776600/
https://www.ncbi.nlm.nih.gov/pubmed/31611870
http://dx.doi.org/10.3389/fimmu.2019.02166
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author Zipfel, Peter F.
Wiech, Thorsten
Rudnick, Ramona
Afonso, Sara
Person, Fermin
Skerka, Christine
author_facet Zipfel, Peter F.
Wiech, Thorsten
Rudnick, Ramona
Afonso, Sara
Person, Fermin
Skerka, Christine
author_sort Zipfel, Peter F.
collection PubMed
description Defective complement action is a cause of several human glomerular diseases including atypical hemolytic uremic syndrome (aHUS), anti-neutrophil cytoplasmic antibody mediated vasculitis (ANCA), C3 glomerulopathy, IgA nephropathy, immune complex membranoproliferative glomerulonephritis, ischemic reperfusion injury, lupus nephritis, membranous nephropathy, and chronic transplant mediated glomerulopathy. Here we summarize ongoing clinical trials of complement inhibitors in nine glomerular diseases and show which inhibitors are used in trials for these renal disorders (http://clinicaltrials.gov).
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spelling pubmed-67766002019-10-14 Complement Inhibitors in Clinical Trials for Glomerular Diseases Zipfel, Peter F. Wiech, Thorsten Rudnick, Ramona Afonso, Sara Person, Fermin Skerka, Christine Front Immunol Immunology Defective complement action is a cause of several human glomerular diseases including atypical hemolytic uremic syndrome (aHUS), anti-neutrophil cytoplasmic antibody mediated vasculitis (ANCA), C3 glomerulopathy, IgA nephropathy, immune complex membranoproliferative glomerulonephritis, ischemic reperfusion injury, lupus nephritis, membranous nephropathy, and chronic transplant mediated glomerulopathy. Here we summarize ongoing clinical trials of complement inhibitors in nine glomerular diseases and show which inhibitors are used in trials for these renal disorders (http://clinicaltrials.gov). Frontiers Media S.A. 2019-09-27 /pmc/articles/PMC6776600/ /pubmed/31611870 http://dx.doi.org/10.3389/fimmu.2019.02166 Text en Copyright © 2019 Zipfel, Wiech, Rudnick, Afonso, Person and Skerka. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Zipfel, Peter F.
Wiech, Thorsten
Rudnick, Ramona
Afonso, Sara
Person, Fermin
Skerka, Christine
Complement Inhibitors in Clinical Trials for Glomerular Diseases
title Complement Inhibitors in Clinical Trials for Glomerular Diseases
title_full Complement Inhibitors in Clinical Trials for Glomerular Diseases
title_fullStr Complement Inhibitors in Clinical Trials for Glomerular Diseases
title_full_unstemmed Complement Inhibitors in Clinical Trials for Glomerular Diseases
title_short Complement Inhibitors in Clinical Trials for Glomerular Diseases
title_sort complement inhibitors in clinical trials for glomerular diseases
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6776600/
https://www.ncbi.nlm.nih.gov/pubmed/31611870
http://dx.doi.org/10.3389/fimmu.2019.02166
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