HERC2 regulates RPA2 by mediating ATR-induced Ser33 phosphorylation and ubiquitin-dependent degradation

Replication protein A (RPA) binds to and stabilizes single-stranded DNA and is essential for the genome stability. We reported that an E3 ubiquitin ligase, HERC2, suppresses G-quadruplex (G4) DNA by regulating RPA-helicase complexes. However, the precise mechanism of HERC2 on RPA is as yet largely u...

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Detalles Bibliográficos
Autores principales: Lai, Yongqiang, Zhu, Mingzhang, Wu, Wenwen, Rokutanda, Nana, Togashi, Yukiko, Liang, Weixin, Ohta, Tomohiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6776656/
https://www.ncbi.nlm.nih.gov/pubmed/31582797
http://dx.doi.org/10.1038/s41598-019-50812-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6776656/
https://www.ncbi.nlm.nih.gov/pubmed/31582797
http://dx.doi.org/10.1038/s41598-019-50812-x

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