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Therapeutic Potential of ω-3 Polyunsaturated Fatty Acids in Human Autoimmune Diseases
The recognition of ω-3 polyunsaturated acids (PUFAs) as essential fatty acids to normal growth and health was realized more than 80 years ago. However, the awareness of the long-term nutritional intake of ω-3 PUFAs in lowering the risk of a variety of chronic human diseases has grown exponentially o...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6776881/ https://www.ncbi.nlm.nih.gov/pubmed/31611873 http://dx.doi.org/10.3389/fimmu.2019.02241 |
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author | Li, Xiaoxi Bi, Xinyun Wang, Shuai Zhang, Zongmeng Li, Fanghong Zhao, Allan Z. |
author_facet | Li, Xiaoxi Bi, Xinyun Wang, Shuai Zhang, Zongmeng Li, Fanghong Zhao, Allan Z. |
author_sort | Li, Xiaoxi |
collection | PubMed |
description | The recognition of ω-3 polyunsaturated acids (PUFAs) as essential fatty acids to normal growth and health was realized more than 80 years ago. However, the awareness of the long-term nutritional intake of ω-3 PUFAs in lowering the risk of a variety of chronic human diseases has grown exponentially only since the 1980s (1, 2). Despite the overwhelming epidemiological evidence, many attempts of using fish-oil supplementation to intervene human diseases have generated conflicting and often ambiguous outcomes; null or weak supporting conclusions were sometimes derived in the subsequent META analysis. Different dosages, as well as the sources of fish-oil, may have contributed to the conflicting outcomes of intervention carried out at different clinics. However, over the past decade, mounting evidence generated from genetic mouse models and clinical studies has shed new light on the functions and the underlying mechanisms of ω-3 PUFAs and their metabolites in the prevention and treatment of rheumatoid arthritis, systemic lupus erythematosus (SLE), multiple sclerosis, and type 1 diabetes. In this review, we have summarized the current understanding of the effects as well as the underlying mechanisms of ω-3 PUFAs on autoimmune diseases. |
format | Online Article Text |
id | pubmed-6776881 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-67768812019-10-14 Therapeutic Potential of ω-3 Polyunsaturated Fatty Acids in Human Autoimmune Diseases Li, Xiaoxi Bi, Xinyun Wang, Shuai Zhang, Zongmeng Li, Fanghong Zhao, Allan Z. Front Immunol Immunology The recognition of ω-3 polyunsaturated acids (PUFAs) as essential fatty acids to normal growth and health was realized more than 80 years ago. However, the awareness of the long-term nutritional intake of ω-3 PUFAs in lowering the risk of a variety of chronic human diseases has grown exponentially only since the 1980s (1, 2). Despite the overwhelming epidemiological evidence, many attempts of using fish-oil supplementation to intervene human diseases have generated conflicting and often ambiguous outcomes; null or weak supporting conclusions were sometimes derived in the subsequent META analysis. Different dosages, as well as the sources of fish-oil, may have contributed to the conflicting outcomes of intervention carried out at different clinics. However, over the past decade, mounting evidence generated from genetic mouse models and clinical studies has shed new light on the functions and the underlying mechanisms of ω-3 PUFAs and their metabolites in the prevention and treatment of rheumatoid arthritis, systemic lupus erythematosus (SLE), multiple sclerosis, and type 1 diabetes. In this review, we have summarized the current understanding of the effects as well as the underlying mechanisms of ω-3 PUFAs on autoimmune diseases. Frontiers Media S.A. 2019-09-27 /pmc/articles/PMC6776881/ /pubmed/31611873 http://dx.doi.org/10.3389/fimmu.2019.02241 Text en Copyright © 2019 Li, Bi, Wang, Zhang, Li and Zhao. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Li, Xiaoxi Bi, Xinyun Wang, Shuai Zhang, Zongmeng Li, Fanghong Zhao, Allan Z. Therapeutic Potential of ω-3 Polyunsaturated Fatty Acids in Human Autoimmune Diseases |
title | Therapeutic Potential of ω-3 Polyunsaturated Fatty Acids in Human Autoimmune Diseases |
title_full | Therapeutic Potential of ω-3 Polyunsaturated Fatty Acids in Human Autoimmune Diseases |
title_fullStr | Therapeutic Potential of ω-3 Polyunsaturated Fatty Acids in Human Autoimmune Diseases |
title_full_unstemmed | Therapeutic Potential of ω-3 Polyunsaturated Fatty Acids in Human Autoimmune Diseases |
title_short | Therapeutic Potential of ω-3 Polyunsaturated Fatty Acids in Human Autoimmune Diseases |
title_sort | therapeutic potential of ω-3 polyunsaturated fatty acids in human autoimmune diseases |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6776881/ https://www.ncbi.nlm.nih.gov/pubmed/31611873 http://dx.doi.org/10.3389/fimmu.2019.02241 |
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