The ubiquitin‐conjugating enzyme UBE2QL1 coordinates lysophagy in response to endolysosomal damage

The autophagic clearance of damaged lysosomes by lysophagy involves extensive modification of the organelle with ubiquitin, but the underlying ubiquitination machinery is still poorly characterized. Here, we use an siRNA screening approach and identify human UBE2QL1 as a major regulator of lysosomal...

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Detalles Bibliográficos
Autores principales: Koerver, Lisa, Papadopoulos, Chrisovalantis, Liu, Bin, Kravic, Bojana, Rota, Giulia, Brecht, Lukas, Veenendaal, Tineke, Polajnar, Mira, Bluemke, Anika, Ehrmann, Michael, Klumperman, Judith, Jäättelä, Marja, Behrends, Christian, Meyer, Hemmo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6776906/
https://www.ncbi.nlm.nih.gov/pubmed/31432621
http://dx.doi.org/10.15252/embr.201948014

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