Developmental Expression of Mutant PFN1 in Motor Neurons Impacts Neuronal Growth and Motor Performance of Young and Adult Mice

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease with limited treatment and no cure. Mutations in profilin 1 were identified as a cause of familial ALS (fALS) in 2012. We investigated the functional impact of mutant profilin 1 expression in spinal cords during mouse dev...

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Detalles Bibliográficos
Autores principales: Brettle, Merryn, Stefen, Holly, Djordjevic, Aleksandra, Fok, Sandra Y. Y., Chan, Josephine W., van Hummel, Annika, van der Hoven, Julia, Przybyla, Magdalena, Volkerling, Alexander, Ke, Yazi D., Delerue, Fabien, Ittner, Lars M., Fath, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6776973/
https://www.ncbi.nlm.nih.gov/pubmed/31611772
http://dx.doi.org/10.3389/fnmol.2019.00231

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