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Structural Perturbations due to Mutation (H1047R) in Phosphoinositide-3-kinase (PI3Kα) and Its Involvement in Oncogenesis: An in Silico Insight

[Image: see text] PI3Kα is a heterodimer protein consisting of two subunits (p110α and p85α) which promotes various signaling pathways. Oncogenic mutation in the catalytic subunit p110α of PI3Kα at the 1047 position in the kinase domain substitutes the histidine with arginine. This mutation brings a...

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Detalles Bibliográficos
Autores principales:	Sharma, Jatin, Bhardwaj, Vijay, Purohit, Rituraj
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2019
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6776984/ https://www.ncbi.nlm.nih.gov/pubmed/31592171 http://dx.doi.org/10.1021/acsomega.9b01439

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