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Case Report: Sarcoidosis mimicking head and neck cancer progression
Several case reports have been published describing the coexistence of sarcoidosis and cancer. In the literature, simultaneous occurrence of head and neck cancer and sarcoidosis is rarely reported. In this paper we present a case of a 42-year-old man with squamous cell carcinoma of the oral cavity,...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
F1000 Research Limited
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6777012/ https://www.ncbi.nlm.nih.gov/pubmed/31608145 http://dx.doi.org/10.12688/f1000research.17834.1 |
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author | Pratas, Edgar Carvalho, João Domingues, Isabel Pinheiro, Sara Amaral, Susana Khouri, Leila Costa, Miguel Eufrásio, José Pires, Isonda Davies, Michael Garcia, Rita Teixeira, Margarida |
author_facet | Pratas, Edgar Carvalho, João Domingues, Isabel Pinheiro, Sara Amaral, Susana Khouri, Leila Costa, Miguel Eufrásio, José Pires, Isonda Davies, Michael Garcia, Rita Teixeira, Margarida |
author_sort | Pratas, Edgar |
collection | PubMed |
description | Several case reports have been published describing the coexistence of sarcoidosis and cancer. In the literature, simultaneous occurrence of head and neck cancer and sarcoidosis is rarely reported. In this paper we present a case of a 42-year-old man with squamous cell carcinoma of the oral cavity, locally advanced, which after surgery and adjuvant radiotherapy developed local persistence and progression in the mediastinal lymph nodes. The patient was submitted to chemotherapy and after a complete response, new suspicious mediastinal and hilar lymph nodes appeared in the thoracic computed tomography (CT) scan and 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) scan. To enroll the patient in a clinical trial, the patient underwent mediastinoscopy with mediastinal lymph node dissection. The histopathological findings were consistent with sarcoidosis and no metastatic disease was found. Since the patient had no symptoms and the levels of serum angiotensin converting enzyme were normal, no further pharmacological intervention was done. After 4 years of follow up the patient remains without evidence of cancer. This case shows that although imagological techniques (CT and FDG-PET scan) are extensively used to assess the tumor response, false-positive cases can occur. Whenever it is possible a biopsy of the suspected metastatic site should always be performed. |
format | Online Article Text |
id | pubmed-6777012 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | F1000 Research Limited |
record_format | MEDLINE/PubMed |
spelling | pubmed-67770122019-10-10 Case Report: Sarcoidosis mimicking head and neck cancer progression Pratas, Edgar Carvalho, João Domingues, Isabel Pinheiro, Sara Amaral, Susana Khouri, Leila Costa, Miguel Eufrásio, José Pires, Isonda Davies, Michael Garcia, Rita Teixeira, Margarida F1000Res Case Report Several case reports have been published describing the coexistence of sarcoidosis and cancer. In the literature, simultaneous occurrence of head and neck cancer and sarcoidosis is rarely reported. In this paper we present a case of a 42-year-old man with squamous cell carcinoma of the oral cavity, locally advanced, which after surgery and adjuvant radiotherapy developed local persistence and progression in the mediastinal lymph nodes. The patient was submitted to chemotherapy and after a complete response, new suspicious mediastinal and hilar lymph nodes appeared in the thoracic computed tomography (CT) scan and 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) scan. To enroll the patient in a clinical trial, the patient underwent mediastinoscopy with mediastinal lymph node dissection. The histopathological findings were consistent with sarcoidosis and no metastatic disease was found. Since the patient had no symptoms and the levels of serum angiotensin converting enzyme were normal, no further pharmacological intervention was done. After 4 years of follow up the patient remains without evidence of cancer. This case shows that although imagological techniques (CT and FDG-PET scan) are extensively used to assess the tumor response, false-positive cases can occur. Whenever it is possible a biopsy of the suspected metastatic site should always be performed. F1000 Research Limited 2019-02-25 /pmc/articles/PMC6777012/ /pubmed/31608145 http://dx.doi.org/10.12688/f1000research.17834.1 Text en Copyright: © 2019 Pratas E et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Pratas, Edgar Carvalho, João Domingues, Isabel Pinheiro, Sara Amaral, Susana Khouri, Leila Costa, Miguel Eufrásio, José Pires, Isonda Davies, Michael Garcia, Rita Teixeira, Margarida Case Report: Sarcoidosis mimicking head and neck cancer progression |
title | Case Report: Sarcoidosis mimicking head and neck cancer progression |
title_full | Case Report: Sarcoidosis mimicking head and neck cancer progression |
title_fullStr | Case Report: Sarcoidosis mimicking head and neck cancer progression |
title_full_unstemmed | Case Report: Sarcoidosis mimicking head and neck cancer progression |
title_short | Case Report: Sarcoidosis mimicking head and neck cancer progression |
title_sort | case report: sarcoidosis mimicking head and neck cancer progression |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6777012/ https://www.ncbi.nlm.nih.gov/pubmed/31608145 http://dx.doi.org/10.12688/f1000research.17834.1 |
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