Discovery of Ligand-Efficient Scaffolds for the Design of Novel Trichomonas vaginalis Uridine Nucleoside Ribohydrolase Inhibitors Using Fragment Screening

[Image: see text] Trichomoniasis is caused by the parasitic protozoan Trichomonas vaginalis. The increasing prevalence of strains resistant to the current 5-nitroimidazole treatments creates the need for novel therapies. T. vaginalis cannot synthesize purine and pyrimidine rings and requires salvage...

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Detalles Bibliográficos
Autores principales: Auletta, Shannon, Caravan, Wagma, Persaud, Julia K., Thuilot, Samantha F., Brown, Dean G., Parkin, David W., Stockman, Brian J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6777076/
https://www.ncbi.nlm.nih.gov/pubmed/31592163
http://dx.doi.org/10.1021/acsomega.9b02472

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