Ligand-Promoted Iridium-Catalyzed Transfer Hydrogenation of Terminal Alkynes with Ethanol and Its Application

[Image: see text] A ligand-promoted iridium-catalyzed transfer hydrogenation of terminal alkynes with ethanol and its application has been developed. Highly chemical selectivity control is achieved based on ligand regulation. 1,2-Bis(diphenylphosphino)ethane was found to be critical for the transfer...

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Autores principales: Wang, Chengniu, Gong, Shengnan, Liang, Zhipeng, Sun, Yufeng, Cheng, Rui, Yang, Banghua, Liu, Yirong, Yang, Jinfei, Sun, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6777128/
https://www.ncbi.nlm.nih.gov/pubmed/31592175
http://dx.doi.org/10.1021/acsomega.9b02191
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author Wang, Chengniu
Gong, Shengnan
Liang, Zhipeng
Sun, Yufeng
Cheng, Rui
Yang, Banghua
Liu, Yirong
Yang, Jinfei
Sun, Fei
author_facet Wang, Chengniu
Gong, Shengnan
Liang, Zhipeng
Sun, Yufeng
Cheng, Rui
Yang, Banghua
Liu, Yirong
Yang, Jinfei
Sun, Fei
author_sort Wang, Chengniu
collection PubMed
description [Image: see text] A ligand-promoted iridium-catalyzed transfer hydrogenation of terminal alkynes with ethanol and its application has been developed. Highly chemical selectivity control is achieved based on ligand regulation. 1,2-Bis(diphenylphosphino)ethane was found to be critical for the transfer hydrogenation of alkynes. The general applicability of this procedure is highlighted by the synthesis of 30 terminal alkenes with a good yield. In addition, we conducted drug effect studies of phenelzine using zebrafish as the vertebrate model. Phenelzine shows a significant effect on promoting vascular proliferation and inhibiting nerve growth. The results of these studies have an important reference value for promoting drug research in cerebrovascular diseases, epilepsy, mania, and psychosis.
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spelling pubmed-67771282019-10-07 Ligand-Promoted Iridium-Catalyzed Transfer Hydrogenation of Terminal Alkynes with Ethanol and Its Application Wang, Chengniu Gong, Shengnan Liang, Zhipeng Sun, Yufeng Cheng, Rui Yang, Banghua Liu, Yirong Yang, Jinfei Sun, Fei ACS Omega [Image: see text] A ligand-promoted iridium-catalyzed transfer hydrogenation of terminal alkynes with ethanol and its application has been developed. Highly chemical selectivity control is achieved based on ligand regulation. 1,2-Bis(diphenylphosphino)ethane was found to be critical for the transfer hydrogenation of alkynes. The general applicability of this procedure is highlighted by the synthesis of 30 terminal alkenes with a good yield. In addition, we conducted drug effect studies of phenelzine using zebrafish as the vertebrate model. Phenelzine shows a significant effect on promoting vascular proliferation and inhibiting nerve growth. The results of these studies have an important reference value for promoting drug research in cerebrovascular diseases, epilepsy, mania, and psychosis. American Chemical Society 2019-09-18 /pmc/articles/PMC6777128/ /pubmed/31592175 http://dx.doi.org/10.1021/acsomega.9b02191 Text en Copyright © 2019 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Wang, Chengniu
Gong, Shengnan
Liang, Zhipeng
Sun, Yufeng
Cheng, Rui
Yang, Banghua
Liu, Yirong
Yang, Jinfei
Sun, Fei
Ligand-Promoted Iridium-Catalyzed Transfer Hydrogenation of Terminal Alkynes with Ethanol and Its Application
title Ligand-Promoted Iridium-Catalyzed Transfer Hydrogenation of Terminal Alkynes with Ethanol and Its Application
title_full Ligand-Promoted Iridium-Catalyzed Transfer Hydrogenation of Terminal Alkynes with Ethanol and Its Application
title_fullStr Ligand-Promoted Iridium-Catalyzed Transfer Hydrogenation of Terminal Alkynes with Ethanol and Its Application
title_full_unstemmed Ligand-Promoted Iridium-Catalyzed Transfer Hydrogenation of Terminal Alkynes with Ethanol and Its Application
title_short Ligand-Promoted Iridium-Catalyzed Transfer Hydrogenation of Terminal Alkynes with Ethanol and Its Application
title_sort ligand-promoted iridium-catalyzed transfer hydrogenation of terminal alkynes with ethanol and its application
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6777128/
https://www.ncbi.nlm.nih.gov/pubmed/31592175
http://dx.doi.org/10.1021/acsomega.9b02191
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