Effect of laparoscopic myomectomy on serum levels of IL-6 and TAC, and ovarian function

Effect of laparoscopic myomectomy on the serum levels of interleukin-6 (IL-6) and total antioxidant capacity (TAC), and the ovarian function of patients with uterine fibroids was studied. Ninety patients with uterine fibroids admitted to The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, from March 2013 to July 2014, were randomly divided into the experimental group (n=45) and the control group (n=45). The experimental group was treated with laparoscopic myomectomy, and the control group was treated with abdominal myomectomy. ELISA was used for detecting IL-6 and TAC content. Radioimmunoassay (RIA) was used for detecting serum ovarian function indicators, including estradiol (E(2)), follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Patients in the experimental group had significantly lower intraoperative blood loss, postoperative exhaust time, number of days to recovery and return to work, number of intraoperative fibroids removed, and length of stay than those in the control group (P<0.05). TAC expression level was significantly higher in the experimental group than that in the control group, on the 1st, 3rd and 5th day after surgery (P<0.05), while IL-6 expression was significantly lower in the experimental group than that in the control group at the same time points (P<0.05). FSH and LH expression levels were significantly lower in the experimental group than those in the control group (P<0.05) at 1, 3 and 6 months after surgery, while E(2) expression level was significantly higher in the experimental group than that in the control group at the same time points (P<0.05). The incidence of postoperative complications of patients in the experimental group was significantly lower than that in the control group (P<0.05). Patients in the experimental group had significantly higher successful pregnancy rate than those in the control group (χ(2)=6.75, P<0.05). Reducing its effect on ovarian function, serum pain index and oxidative damage index of patients with uterine fibroid, laparoscopic myomectomy also reduces the incidence of postoperative complications and increases the pregnancy rate.