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Factors affecting the therapeutic effect of botulinum toxin A on trigeminal neuralgia: A follow-up retrospective study of 152 patients

Botulinum toxin A (BTX-A) is a promising therapeutic modality against trigeminal neuralgia (TN) with certain controversies pertaining to its application. To provide further information on factors influencing the treatment outcomes of BTX-A, a retrospective study with 152 patients with TN treated wit...

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Autores principales: Zhang, Haifeng, Lian, Yajun, Xie, Nanchang, Cheng, Xuan, Chen, Chen, Xu, Hongliang, Zheng, Yake
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6777303/
https://www.ncbi.nlm.nih.gov/pubmed/31602211
http://dx.doi.org/10.3892/etm.2019.7988
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author Zhang, Haifeng
Lian, Yajun
Xie, Nanchang
Cheng, Xuan
Chen, Chen
Xu, Hongliang
Zheng, Yake
author_facet Zhang, Haifeng
Lian, Yajun
Xie, Nanchang
Cheng, Xuan
Chen, Chen
Xu, Hongliang
Zheng, Yake
author_sort Zhang, Haifeng
collection PubMed
description Botulinum toxin A (BTX-A) is a promising therapeutic modality against trigeminal neuralgia (TN) with certain controversies pertaining to its application. To provide further information on factors influencing the treatment outcomes of BTX-A, a retrospective study with 152 patients with TN treated with BTX-A was performed. The starting time and duration of the therapeutic effect, as well as side effects, of BTX-A in the treatment of TN were analyzed by sex, age, course of disease, number of branches and injected dose. A total of 136 patients exhibited symptom improvement within 2 weeks following BTX-A treatment as evaluated using a visual analog scale (VAS). The effect of BTX-A was sustained throughout the initial 6 months of the follow-up and was demonstrated to persist for as long as 28 months. Female sex, short disease course and high injection dose (>70 units) were associated with lower long-term VAS scores. Patients receiving short-term medium-(50–70 units) or high-dose injections were more likely to be completely cured. Patients with a median disease course (1–10 years) or multiple branches were more likely to exhibit facial asymmetry. Based on the stratified analysis, female patients with a median disease course (1–10 years) exhibited a higher incidence of side effects and male patients achieved better treatment outcomes with high BTX-A doses. BTX-A effectively alleviated patients with TN in both short or long term, although the treatment efficacy may depend on patient characteristics.
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spelling pubmed-67773032019-10-10 Factors affecting the therapeutic effect of botulinum toxin A on trigeminal neuralgia: A follow-up retrospective study of 152 patients Zhang, Haifeng Lian, Yajun Xie, Nanchang Cheng, Xuan Chen, Chen Xu, Hongliang Zheng, Yake Exp Ther Med Articles Botulinum toxin A (BTX-A) is a promising therapeutic modality against trigeminal neuralgia (TN) with certain controversies pertaining to its application. To provide further information on factors influencing the treatment outcomes of BTX-A, a retrospective study with 152 patients with TN treated with BTX-A was performed. The starting time and duration of the therapeutic effect, as well as side effects, of BTX-A in the treatment of TN were analyzed by sex, age, course of disease, number of branches and injected dose. A total of 136 patients exhibited symptom improvement within 2 weeks following BTX-A treatment as evaluated using a visual analog scale (VAS). The effect of BTX-A was sustained throughout the initial 6 months of the follow-up and was demonstrated to persist for as long as 28 months. Female sex, short disease course and high injection dose (>70 units) were associated with lower long-term VAS scores. Patients receiving short-term medium-(50–70 units) or high-dose injections were more likely to be completely cured. Patients with a median disease course (1–10 years) or multiple branches were more likely to exhibit facial asymmetry. Based on the stratified analysis, female patients with a median disease course (1–10 years) exhibited a higher incidence of side effects and male patients achieved better treatment outcomes with high BTX-A doses. BTX-A effectively alleviated patients with TN in both short or long term, although the treatment efficacy may depend on patient characteristics. D.A. Spandidos 2019-11 2019-09-09 /pmc/articles/PMC6777303/ /pubmed/31602211 http://dx.doi.org/10.3892/etm.2019.7988 Text en Copyright: © Zhang et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Zhang, Haifeng
Lian, Yajun
Xie, Nanchang
Cheng, Xuan
Chen, Chen
Xu, Hongliang
Zheng, Yake
Factors affecting the therapeutic effect of botulinum toxin A on trigeminal neuralgia: A follow-up retrospective study of 152 patients
title Factors affecting the therapeutic effect of botulinum toxin A on trigeminal neuralgia: A follow-up retrospective study of 152 patients
title_full Factors affecting the therapeutic effect of botulinum toxin A on trigeminal neuralgia: A follow-up retrospective study of 152 patients
title_fullStr Factors affecting the therapeutic effect of botulinum toxin A on trigeminal neuralgia: A follow-up retrospective study of 152 patients
title_full_unstemmed Factors affecting the therapeutic effect of botulinum toxin A on trigeminal neuralgia: A follow-up retrospective study of 152 patients
title_short Factors affecting the therapeutic effect of botulinum toxin A on trigeminal neuralgia: A follow-up retrospective study of 152 patients
title_sort factors affecting the therapeutic effect of botulinum toxin a on trigeminal neuralgia: a follow-up retrospective study of 152 patients
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6777303/
https://www.ncbi.nlm.nih.gov/pubmed/31602211
http://dx.doi.org/10.3892/etm.2019.7988
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