The Importance of microRNAs in RAS Oncogenic Activation in Human Cancer

microRNAs (miRNAs) regulate gene expression by modulating the translation of protein-coding RNAs. Their aberrant expression is involved in various human diseases, including cancer. Here, we summarize the experimental pieces of evidence that proved how dysregulated miRNA expression can lead to RAS (H...

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Autores principales: Roncarati, Roberta, Lupini, Laura, Shankaraiah, Ram C., Negrini, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6777413/
https://www.ncbi.nlm.nih.gov/pubmed/31612113
http://dx.doi.org/10.3389/fonc.2019.00988
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author Roncarati, Roberta
Lupini, Laura
Shankaraiah, Ram C.
Negrini, Massimo
author_facet Roncarati, Roberta
Lupini, Laura
Shankaraiah, Ram C.
Negrini, Massimo
author_sort Roncarati, Roberta
collection PubMed
description microRNAs (miRNAs) regulate gene expression by modulating the translation of protein-coding RNAs. Their aberrant expression is involved in various human diseases, including cancer. Here, we summarize the experimental pieces of evidence that proved how dysregulated miRNA expression can lead to RAS (HRAS, KRAS, or NRAS) activation irrespective of their oncogenic mutations. These findings revealed relevant pathogenic mechanisms as well as mechanisms of resistance to target therapies. Based on this knowledge, potential approaches for the control of RAS oncogenic activation can be envisioned.
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spelling pubmed-67774132019-10-14 The Importance of microRNAs in RAS Oncogenic Activation in Human Cancer Roncarati, Roberta Lupini, Laura Shankaraiah, Ram C. Negrini, Massimo Front Oncol Oncology microRNAs (miRNAs) regulate gene expression by modulating the translation of protein-coding RNAs. Their aberrant expression is involved in various human diseases, including cancer. Here, we summarize the experimental pieces of evidence that proved how dysregulated miRNA expression can lead to RAS (HRAS, KRAS, or NRAS) activation irrespective of their oncogenic mutations. These findings revealed relevant pathogenic mechanisms as well as mechanisms of resistance to target therapies. Based on this knowledge, potential approaches for the control of RAS oncogenic activation can be envisioned. Frontiers Media S.A. 2019-09-27 /pmc/articles/PMC6777413/ /pubmed/31612113 http://dx.doi.org/10.3389/fonc.2019.00988 Text en Copyright © 2019 Roncarati, Lupini, Shankaraiah and Negrini. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Roncarati, Roberta
Lupini, Laura
Shankaraiah, Ram C.
Negrini, Massimo
The Importance of microRNAs in RAS Oncogenic Activation in Human Cancer
title The Importance of microRNAs in RAS Oncogenic Activation in Human Cancer
title_full The Importance of microRNAs in RAS Oncogenic Activation in Human Cancer
title_fullStr The Importance of microRNAs in RAS Oncogenic Activation in Human Cancer
title_full_unstemmed The Importance of microRNAs in RAS Oncogenic Activation in Human Cancer
title_short The Importance of microRNAs in RAS Oncogenic Activation in Human Cancer
title_sort importance of micrornas in ras oncogenic activation in human cancer
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6777413/
https://www.ncbi.nlm.nih.gov/pubmed/31612113
http://dx.doi.org/10.3389/fonc.2019.00988
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