Cargando…

Kappa opioid receptor agonists improve postoperative cognitive dysfunction in rats via the JAK2/STAT3 signaling pathway

Postoperative cognitive dysfunction (POCD) is a common and well-known complication following surgery, particularly cardiopulmonary bypass (CPB) surgery. There are currently no suitable treatments for POCD, which is associated with increased illness and mortality rates. The present study aimed to ide...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Xi, Sun, Yingjie, Jin, Qiang, Song, Dandan, Diao, Yugang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2019
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6777679/ https://www.ncbi.nlm.nih.gov/pubmed/31545485 http://dx.doi.org/10.3892/ijmm.2019.4339

Ejemplares similares

κ-opioid receptor agonist U50488H attenuates postoperative cognitive dysfunction of cardiopulmonary bypass rats through the PI3K/AKT/Nrf2/HO-1 pathway
por: Fan, Jianing, et al.
Publicado: (2021)

κ-opioid receptor agonists may alleviate intestinal damage in cardiopulmonary bypass rats by inhibiting the NF-κB/HIF-1α pathway
por: Zhang, Xiaoyan, et al.
Publicado: (2020)

Reversing Postcardiopulmonary Bypass Associated Cognitive Dysfunction Using k-Opioid Receptor Agonists to Regulate Microglial Polarization via the NLRP3/Caspase-1 Pathway
por: Song, Pei, et al.
Publicado: (2021)

Therapeutic Potential of Kappa Opioid Agonists
por: Beck, Tyler C., et al.
Publicado: (2019)

Orvinols with Mixed Kappa/Mu Opioid Receptor Agonist Activity
por: Greedy, Benjamin M., et al.
Publicado: (2013)

κ-Opioid Receptor Agonist Ameliorates Postoperative Neurocognitive Disorder by Activating the Ca(2+)/CaMKII/CREB Pathway
por: Ding, Guopeng, et al.
Publicado: (2021)

Effects of mu- and kappa-2 opioid receptor agonists on pain and rearing behaviors
por: Neubert, John K, et al.
Publicado: (2007)

Novel Kappa-Opioid Receptor Agonist for the Treatment of Cholestatic Pruritus: Systematic Review
por: Bailey, Adrian Joseph Michel, et al.
Publicado: (2022)

α7 nicotinic acetylcholine receptor agonist inhibits the damage of rat hippocampal neurons by TLR4/Myd88/NF-κB signaling pathway during cardiopulmonary bypass
por: Chen, Keyan, et al.
Publicado: (2017)

Topical administration of the kappa opioid receptor agonist nalfurafine suppresses corneal neovascularization and inflammation
por: Shokirova, Hurramhon, et al.
Publicado: (2021)

Characterization of Pyrrolidinyl-hexahydro-pyranopiperazines as a Novel Kappa Opioid Receptor Agonist Scaffold
por: Reed, Brian, et al.
Publicado: (2022)

Behavioral Pharmacology of Novel Kappa Opioid Receptor Antagonists in Rats
por: Page, Sarah, et al.
Publicado: (2019)

Diuretic Activity of a Novel Peripherally-Restricted Orally-Active Kappa Opioid Receptor Agonist
por: Beck, Tyler C., et al.
Publicado: (2019)

Antipruritic Effect of Nalbuphine, a Kappa Opioid Receptor Agonist, in Mice: A Pan Antipruritic
por: Inan, Saadet, et al.
Publicado: (2021)

Pharmacological profiles of opioid ligands at Kappa opioid receptors
por: Gharagozlou, Parham, et al.
Publicado: (2006)

Kappa Opioid Receptor on Pulmonary Macrophages and Immune Function
por: Zeng, Si, et al.
Publicado: (2020)

Development of a Peptide-Derived Orally-Active Kappa-Opioid Receptor Agonist Targeting Peripheral Pain
por: Hughes, Jr, Francis M., et al.
Publicado: (2013)

Evaluation of the abuse potential of difelikefalin, a selective kappa‐opioid receptor agonist, in recreational polydrug users
por: Shram, Megan J., et al.
Publicado: (2021)

Sex Differences in Kappa Opioid Receptor Agonist Mediated Attenuation of Chemotherapy-Induced Neuropathic Pain in Mice
por: Paton, Kelly F., et al.
Publicado: (2022)

nor-BNI Antagonism of Kappa Opioid Agonist-Induced Reinstatement of Ethanol-Seeking Behavior
por: Harshberger, Erin, et al.
Publicado: (2016)

Renal responses produced by microinjection of the kappa opioid receptor agonist, U50-488H, into sites within the rat lamina terminalis
por: Franklin, Cynthia, et al.
Publicado: (2015)

Structure of the human kappa opioid receptor in complex with JDTic
por: Wu, Huixian, et al.
Publicado: (2012)

Cardioprotection by kappa-opioid receptor agonist U50488H is mediated by opioidergic regulation but not by calcium current modulation
por: Chun, Kook Jin, et al.
Publicado: (2010)

The Differential Effects of a Selective Kappa-Opioid Receptor Agonist, U50488, in Guinea Pig Heart Tissues
por: Hung, Chi-Feng, et al.
Publicado: (2015)

Agonist-Promoted Phosphorylation and Internalization of the Kappa Opioid Receptor in Mouse Brains: Lack of Connection With Conditioned Place Aversion
por: Chen, Chongguang, et al.
Publicado: (2022)

Discovery of 7-Azanorbornane-Based Dual Agonists for the Delta and Kappa Opioid Receptors through an In Situ Screening Protocol
por: Karaki, Fumika, et al.
Publicado: (2023)

The role of kappa opioid receptors in stress-induced reinstatement of alcohol seeking in rats
por: Funk, Douglas, et al.
Publicado: (2014)

Kappa opioid receptor antagonism: Are opioids the answer for treatment resistant depression?
por: Peckham, Alyssa M., et al.
Publicado: (2018)

Ventral Hippocampal Kappa Opioid Receptors Mediate the Renewal of Fear following Extinction in the Rat
por: Cole, Sindy, et al.
Publicado: (2013)

Identification of novel ligands interacting with kappa opioid receptors
por: Spetea, Mariana, et al.
Publicado: (2011)

Major Depressive Disorder and Kappa Opioid Receptor Antagonists
por: Li, Wei, et al.
Publicado: (2016)

The Kappa Opioid Receptor: From Addiction to Depression, and Back
por: Lalanne, Laurence, et al.
Publicado: (2014)

Nanobody-enabled monitoring of kappa opioid receptor states
por: Che, Tao, et al.
Publicado: (2020)

Pharmacology of Kappa Opioid Receptors: Novel Assays and Ligands
por: Sturaro, Chiara, et al.
Publicado: (2022)

Molecular mechanism of biased signaling at the kappa opioid receptor
por: El Daibani, Amal, et al.
Publicado: (2023)

Cell-penetrating interactomic inhibition of nuclear factor-kappa B in a mouse model of postoperative cognitive dysfunction
por: Cheon, So Yeong, et al.
Publicado: (2017)

Inhibition of the JAK/STAT Pathway With Baricitinib Reduces the Multiple Organ Dysfunction Caused by Hemorrhagic Shock in Rats
por: Patel, Nikita M., et al.
Publicado: (2023)

JAKs and STATs in chemoresistance
por: Costa-Pereira, Ana P
Publicado: (2010)

JAK-STAT and feeding
por: Ladyman, Sharon R., et al.
Publicado: (2013)

Salvinorin A, a kappa-opioid receptor agonist hallucinogen: pharmacology and potential template for novel pharmacotherapeutic agents in neuropsychiatric disorders
por: Butelman, Eduardo R., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_n9sj51ai3gnc6mcpebtsusncu2