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Inter-Individual Responses to Citrulline Malate Oral Supplementation on Post-Exercise Hypotension in Hypertensives: A 24-Hour Analysis
BACKGROUND: Studies have persuasively demonstrated that citrulline has a key role in the arginine-nitric oxide system, increasing nitric oxide bioavailability, an important mediator of peripheral vasodilation. OBJECTIVE: To analyze the inter-individual post-exercise hypotension responsiveness follow...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira de Cardiologia - SBC
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6777875/ https://www.ncbi.nlm.nih.gov/pubmed/31291417 http://dx.doi.org/10.5935/abc.20190115 |
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author | Casonatto, Juliano Enokida, Daniel Massaharu Grandolfi, Kamila |
author_facet | Casonatto, Juliano Enokida, Daniel Massaharu Grandolfi, Kamila |
author_sort | Casonatto, Juliano |
collection | PubMed |
description | BACKGROUND: Studies have persuasively demonstrated that citrulline has a key role in the arginine-nitric oxide system, increasing nitric oxide bioavailability, an important mediator of peripheral vasodilation. OBJECTIVE: To analyze the inter-individual post-exercise hypotension responsiveness following acute citrulline supplementation in hypertensives. METHODS: Forty hypertensives were randomly assigned to one of the four experimental groups (control-placebo, control-citrulline, exercise-placebo, and exercise-citrulline). They ingested placebo or citrulline malate [CM] (6 grams). During the exercise session, individuals performed 40 minutes of walking/running on a treadmill at 60-70% of HR reserve. For the control session, the individuals remained seated at rest for 40 minutes. Office blood pressure (BP) was taken every 10 minutes until completing 60 minutes after the experimental session. The ambulatory BP device was programmed to take the readings every 20 minutes (awake time) and every 30 minutes (sleep time) over the course of 24 hours of monitoring. Statistical significance was defined as p < 0.05. RESULTS: Unlike the other experimental groups, there were no “non-responders” in the exercise/citrulline (EC) for “awake” (systolic and diastolic BP) and “24 hours” (diastolic BP). The effect sizes were more consistent in the EC for systolic and diastolic ambulatorial BP response. The effects were “large” (> 0.8) for “awake”, “asleep”, and “24 hours” only in the EC for diastolic BP. CONCLUSION: CM supplementation can increase the post-exercise hypotensive effects in hypertensives. In addition, the prevalence of non-responders is lower when associated with aerobic exercise and CM supplementation. |
format | Online Article Text |
id | pubmed-6777875 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Sociedade Brasileira de Cardiologia - SBC |
record_format | MEDLINE/PubMed |
spelling | pubmed-67778752019-10-09 Inter-Individual Responses to Citrulline Malate Oral Supplementation on Post-Exercise Hypotension in Hypertensives: A 24-Hour Analysis Casonatto, Juliano Enokida, Daniel Massaharu Grandolfi, Kamila Arq Bras Cardiol Original Article BACKGROUND: Studies have persuasively demonstrated that citrulline has a key role in the arginine-nitric oxide system, increasing nitric oxide bioavailability, an important mediator of peripheral vasodilation. OBJECTIVE: To analyze the inter-individual post-exercise hypotension responsiveness following acute citrulline supplementation in hypertensives. METHODS: Forty hypertensives were randomly assigned to one of the four experimental groups (control-placebo, control-citrulline, exercise-placebo, and exercise-citrulline). They ingested placebo or citrulline malate [CM] (6 grams). During the exercise session, individuals performed 40 minutes of walking/running on a treadmill at 60-70% of HR reserve. For the control session, the individuals remained seated at rest for 40 minutes. Office blood pressure (BP) was taken every 10 minutes until completing 60 minutes after the experimental session. The ambulatory BP device was programmed to take the readings every 20 minutes (awake time) and every 30 minutes (sleep time) over the course of 24 hours of monitoring. Statistical significance was defined as p < 0.05. RESULTS: Unlike the other experimental groups, there were no “non-responders” in the exercise/citrulline (EC) for “awake” (systolic and diastolic BP) and “24 hours” (diastolic BP). The effect sizes were more consistent in the EC for systolic and diastolic ambulatorial BP response. The effects were “large” (> 0.8) for “awake”, “asleep”, and “24 hours” only in the EC for diastolic BP. CONCLUSION: CM supplementation can increase the post-exercise hypotensive effects in hypertensives. In addition, the prevalence of non-responders is lower when associated with aerobic exercise and CM supplementation. Sociedade Brasileira de Cardiologia - SBC 2019-08 /pmc/articles/PMC6777875/ /pubmed/31291417 http://dx.doi.org/10.5935/abc.20190115 Text en http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivative License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium provided the original work is properly cited and the work is not changed in any way. |
spellingShingle | Original Article Casonatto, Juliano Enokida, Daniel Massaharu Grandolfi, Kamila Inter-Individual Responses to Citrulline Malate Oral Supplementation on Post-Exercise Hypotension in Hypertensives: A 24-Hour Analysis |
title | Inter-Individual Responses to Citrulline Malate Oral Supplementation
on Post-Exercise Hypotension in Hypertensives: A 24-Hour
Analysis |
title_full | Inter-Individual Responses to Citrulline Malate Oral Supplementation
on Post-Exercise Hypotension in Hypertensives: A 24-Hour
Analysis |
title_fullStr | Inter-Individual Responses to Citrulline Malate Oral Supplementation
on Post-Exercise Hypotension in Hypertensives: A 24-Hour
Analysis |
title_full_unstemmed | Inter-Individual Responses to Citrulline Malate Oral Supplementation
on Post-Exercise Hypotension in Hypertensives: A 24-Hour
Analysis |
title_short | Inter-Individual Responses to Citrulline Malate Oral Supplementation
on Post-Exercise Hypotension in Hypertensives: A 24-Hour
Analysis |
title_sort | inter-individual responses to citrulline malate oral supplementation
on post-exercise hypotension in hypertensives: a 24-hour
analysis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6777875/ https://www.ncbi.nlm.nih.gov/pubmed/31291417 http://dx.doi.org/10.5935/abc.20190115 |
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