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Role of Naltrexone in Improving Compulsive Drinking in Psychogenic Polydipsia

Psychogenic polydipsia or self-induced water intoxication is a potentially lethal condition seen in many chronic psychiatric patients. This is a literature review based on therapeutic significance of Naltrexone in improving compulsive water drinking behavior in chronic psychiatrically ill patients w...

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Detalles Bibliográficos
Autores principales: Rizvi, Sukaina, Gold, Jeffrey, Khan, Ali M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6777931/
https://www.ncbi.nlm.nih.gov/pubmed/31598428
http://dx.doi.org/10.7759/cureus.5320
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author Rizvi, Sukaina
Gold, Jeffrey
Khan, Ali M
author_facet Rizvi, Sukaina
Gold, Jeffrey
Khan, Ali M
author_sort Rizvi, Sukaina
collection PubMed
description Psychogenic polydipsia or self-induced water intoxication is a potentially lethal condition seen in many chronic psychiatric patients. This is a literature review based on therapeutic significance of Naltrexone in improving compulsive water drinking behavior in chronic psychiatrically ill patients with psychogenic polydipsia. Naltrexone is an opioid antagonist approved by FDA for alcohol dependence. Extensive literature search provides a line of evidence that suggests correlation of opioid receptor with compulsive water ingestion in animals. However, there is limited data regarding clinical utility of naltrexone in improving psychogenic polydipsia in human species. This review highlights the necessity for further research and trials to elucidate the role of naltrexone in human psychogenic drinking behavior.
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spelling pubmed-67779312019-10-09 Role of Naltrexone in Improving Compulsive Drinking in Psychogenic Polydipsia Rizvi, Sukaina Gold, Jeffrey Khan, Ali M Cureus Internal Medicine Psychogenic polydipsia or self-induced water intoxication is a potentially lethal condition seen in many chronic psychiatric patients. This is a literature review based on therapeutic significance of Naltrexone in improving compulsive water drinking behavior in chronic psychiatrically ill patients with psychogenic polydipsia. Naltrexone is an opioid antagonist approved by FDA for alcohol dependence. Extensive literature search provides a line of evidence that suggests correlation of opioid receptor with compulsive water ingestion in animals. However, there is limited data regarding clinical utility of naltrexone in improving psychogenic polydipsia in human species. This review highlights the necessity for further research and trials to elucidate the role of naltrexone in human psychogenic drinking behavior. Cureus 2019-08-05 /pmc/articles/PMC6777931/ /pubmed/31598428 http://dx.doi.org/10.7759/cureus.5320 Text en Copyright © 2019, Rizvi et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Rizvi, Sukaina
Gold, Jeffrey
Khan, Ali M
Role of Naltrexone in Improving Compulsive Drinking in Psychogenic Polydipsia
title Role of Naltrexone in Improving Compulsive Drinking in Psychogenic Polydipsia
title_full Role of Naltrexone in Improving Compulsive Drinking in Psychogenic Polydipsia
title_fullStr Role of Naltrexone in Improving Compulsive Drinking in Psychogenic Polydipsia
title_full_unstemmed Role of Naltrexone in Improving Compulsive Drinking in Psychogenic Polydipsia
title_short Role of Naltrexone in Improving Compulsive Drinking in Psychogenic Polydipsia
title_sort role of naltrexone in improving compulsive drinking in psychogenic polydipsia
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6777931/
https://www.ncbi.nlm.nih.gov/pubmed/31598428
http://dx.doi.org/10.7759/cureus.5320
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