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Role of Naltrexone in Improving Compulsive Drinking in Psychogenic Polydipsia
Psychogenic polydipsia or self-induced water intoxication is a potentially lethal condition seen in many chronic psychiatric patients. This is a literature review based on therapeutic significance of Naltrexone in improving compulsive water drinking behavior in chronic psychiatrically ill patients w...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6777931/ https://www.ncbi.nlm.nih.gov/pubmed/31598428 http://dx.doi.org/10.7759/cureus.5320 |
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author | Rizvi, Sukaina Gold, Jeffrey Khan, Ali M |
author_facet | Rizvi, Sukaina Gold, Jeffrey Khan, Ali M |
author_sort | Rizvi, Sukaina |
collection | PubMed |
description | Psychogenic polydipsia or self-induced water intoxication is a potentially lethal condition seen in many chronic psychiatric patients. This is a literature review based on therapeutic significance of Naltrexone in improving compulsive water drinking behavior in chronic psychiatrically ill patients with psychogenic polydipsia. Naltrexone is an opioid antagonist approved by FDA for alcohol dependence. Extensive literature search provides a line of evidence that suggests correlation of opioid receptor with compulsive water ingestion in animals. However, there is limited data regarding clinical utility of naltrexone in improving psychogenic polydipsia in human species. This review highlights the necessity for further research and trials to elucidate the role of naltrexone in human psychogenic drinking behavior. |
format | Online Article Text |
id | pubmed-6777931 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-67779312019-10-09 Role of Naltrexone in Improving Compulsive Drinking in Psychogenic Polydipsia Rizvi, Sukaina Gold, Jeffrey Khan, Ali M Cureus Internal Medicine Psychogenic polydipsia or self-induced water intoxication is a potentially lethal condition seen in many chronic psychiatric patients. This is a literature review based on therapeutic significance of Naltrexone in improving compulsive water drinking behavior in chronic psychiatrically ill patients with psychogenic polydipsia. Naltrexone is an opioid antagonist approved by FDA for alcohol dependence. Extensive literature search provides a line of evidence that suggests correlation of opioid receptor with compulsive water ingestion in animals. However, there is limited data regarding clinical utility of naltrexone in improving psychogenic polydipsia in human species. This review highlights the necessity for further research and trials to elucidate the role of naltrexone in human psychogenic drinking behavior. Cureus 2019-08-05 /pmc/articles/PMC6777931/ /pubmed/31598428 http://dx.doi.org/10.7759/cureus.5320 Text en Copyright © 2019, Rizvi et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Internal Medicine Rizvi, Sukaina Gold, Jeffrey Khan, Ali M Role of Naltrexone in Improving Compulsive Drinking in Psychogenic Polydipsia |
title | Role of Naltrexone in Improving Compulsive Drinking in Psychogenic Polydipsia |
title_full | Role of Naltrexone in Improving Compulsive Drinking in Psychogenic Polydipsia |
title_fullStr | Role of Naltrexone in Improving Compulsive Drinking in Psychogenic Polydipsia |
title_full_unstemmed | Role of Naltrexone in Improving Compulsive Drinking in Psychogenic Polydipsia |
title_short | Role of Naltrexone in Improving Compulsive Drinking in Psychogenic Polydipsia |
title_sort | role of naltrexone in improving compulsive drinking in psychogenic polydipsia |
topic | Internal Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6777931/ https://www.ncbi.nlm.nih.gov/pubmed/31598428 http://dx.doi.org/10.7759/cureus.5320 |
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