A Comprehensive Analysis of Ontogeny of Renal Drug Transporters: mRNA Analyses, Quantitative Proteomics, and Localization

Human renal membrane transporters play key roles in the disposition of renally cleared drugs and endogenous substrates, but their ontogeny is largely unknown. Using 184 human postmortem frozen renal cortical tissues (preterm newborns to adults) and a subset of 62 tissue samples, we measured the mRNA...

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Detalles Bibliográficos
Autores principales: Cheung, Kit Wun Kathy, van Groen, Bianca D., Spaans, Edwin, van Borselen, Marjolein D., de Bruijn, Adrianus C.J.M., Simons‐Oosterhuis, Ytje, Tibboel, Dick, Samsom, Janneke N., Verdijk, Robert M., Smeets, Bart, Zhang, Lei, Huang, Shiew‐Mei, Giacomini, Kathleen M., de Wildt, Saskia N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6777991/
https://www.ncbi.nlm.nih.gov/pubmed/31127606
http://dx.doi.org/10.1002/cpt.1516

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