BIN1 recovers tauopathy-induced long-term memory deficits in mice and interacts with Tau through Thr(348) phosphorylation

The bridging integrator 1 gene (BIN1) is a major genetic risk factor for Alzheimer’s disease (AD). In this report, we investigated how BIN1-dependent pathophysiological processes might be associated with Tau. We first generated a cohort of control and transgenic mice either overexpressing human MAPT...

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Detalles Bibliográficos
Autores principales: Sartori, Maxime, Mendes, Tiago, Desai, Shruti, Lasorsa, Alessia, Herledan, Adrien, Malmanche, Nicolas, Mäkinen, Petra, Marttinen, Mikael, Malki, Idir, Chapuis, Julien, Flaig, Amandine, Vreulx, Anaïs-Camille, Ciancia, Marion, Amouyel, Philippe, Leroux, Florence, Déprez, Benoit, Cantrelle, François-Xavier, Maréchal, Damien, Pradier, Laurent, Hiltunen, Mikko, Landrieu, Isabelle, Kilinc, Devrim, Herault, Yann, Laporte, Jocelyn, Lambert, Jean-Charles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2019
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778065/
https://www.ncbi.nlm.nih.gov/pubmed/31065832
http://dx.doi.org/10.1007/s00401-019-02017-9

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