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Mouse embryo geometry drives formation of robust signaling gradients through receptor localization
Morphogen signals are essential for cell fate specification during embryogenesis. Some receptors that sense these morphogens are known to localize to only the apical or basolateral membrane of polarized cell lines in vitro. How such localization affects morphogen sensing and patterning in the develo...
Autores principales: | Zhang, Zhechun, Zwick, Steven, Loew, Ethan, Grimley, Joshua S., Ramanathan, Sharad |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778081/ https://www.ncbi.nlm.nih.gov/pubmed/31586065 http://dx.doi.org/10.1038/s41467-019-12533-7 |
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