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Aldehyde-alcohol dehydrogenase forms a high-order spirosome architecture critical for its activity

Aldehyde-alcohol dehydrogenase (AdhE) is a key enzyme in bacterial fermentation, converting acetyl-CoA to ethanol, via two consecutive catalytic reactions. Here, we present a 3.5 Å resolution cryo-EM structure of full-length AdhE revealing a high-order spirosome architecture. The structure shows tha...

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Detalles Bibliográficos
Autores principales: Kim, Gijeong, Azmi, Liyana, Jang, Seongmin, Jung, Taeyang, Hebert, Hans, Roe, Andrew J., Byron, Olwyn, Song, Ji-Joon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778083/
https://www.ncbi.nlm.nih.gov/pubmed/31586059
http://dx.doi.org/10.1038/s41467-019-12427-8