Engineering selective competitors for the discrimination of highly conserved protein-protein interaction modules

Designing highly specific modulators of protein-protein interactions (PPIs) is especially challenging in the context of multiple paralogs and conserved interaction surfaces. In this case, direct generation of selective and competitive inhibitors is hindered by high similarity within the evolutionary...

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Detalles Bibliográficos
Autores principales: Rimbault, Charlotte, Maruthi, Kashyap, Breillat, Christelle, Genuer, Camille, Crespillo, Sara, Puente-Muñoz, Virginia, Chamma, Ingrid, Gauthereau, Isabel, Antoine, Ségolène, Thibaut, Coraline, Tai, Fabienne Wong Jun, Dartigues, Benjamin, Grillo-Bosch, Dolors, Claverol, Stéphane, Poujol, Christel, Choquet, Daniel, Mackereth, Cameron D., Sainlos, Matthieu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778148/
https://www.ncbi.nlm.nih.gov/pubmed/31586061
http://dx.doi.org/10.1038/s41467-019-12528-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778148/
https://www.ncbi.nlm.nih.gov/pubmed/31586061
http://dx.doi.org/10.1038/s41467-019-12528-4

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