Conversion of Sox2-dependent Merkel cell carcinoma to a differentiated neuron-like phenotype by T antigen inhibition

Viral cancers show oncogene addiction to viral oncoproteins, which are required for survival and proliferation of the dedifferentiated cancer cell. Human Merkel cell carcinomas (MCCs) that harbor a clonally integrated Merkel cell polyomavirus (MCV) genome have low mutation burden and require viral T...

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Detalles Bibliográficos
Autores principales: Harold, Alexis, Amako, Yutaka, Hachisuka, Junichi, Bai, Yulong, Li, Meng Yen, Kubat, Linda, Gravemeyer, Jan, Franks, Jonathan, Gibbs, Julia R., Park, Hyun Jung, Ezhkova, Elena, Becker, Jürgen C., Shuda, Masahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778204/
https://www.ncbi.nlm.nih.gov/pubmed/31527246
http://dx.doi.org/10.1073/pnas.1907154116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778204/
https://www.ncbi.nlm.nih.gov/pubmed/31527246
http://dx.doi.org/10.1073/pnas.1907154116

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