Cargando…

Conversion of Sox2-dependent Merkel cell carcinoma to a differentiated neuron-like phenotype by T antigen inhibition

Viral cancers show oncogene addiction to viral oncoproteins, which are required for survival and proliferation of the dedifferentiated cancer cell. Human Merkel cell carcinomas (MCCs) that harbor a clonally integrated Merkel cell polyomavirus (MCV) genome have low mutation burden and require viral T...

Descripción completa

Detalles Bibliográficos
Autores principales:	Harold, Alexis, Amako, Yutaka, Hachisuka, Junichi, Bai, Yulong, Li, Meng Yen, Kubat, Linda, Gravemeyer, Jan, Franks, Jonathan, Gibbs, Julia R., Park, Hyun Jung, Ezhkova, Elena, Becker, Jürgen C., Shuda, Masahiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2019
Materias:	PNAS Plus
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778204/ https://www.ncbi.nlm.nih.gov/pubmed/31527246 http://dx.doi.org/10.1073/pnas.1907154116

Ejemplares similares

Cancer-associated fibroblasts suppress SOX2-induced dysplasia in a lung squamous cancer coculture
por: Chen, Shuang, et al.
Publicado: (2018)

Characterization of a Merkel Cell Polyomavirus-Positive Merkel Cell Carcinoma Cell Line CVG-1
por: Velásquez, Celestino, et al.
Publicado: (2018)

Enabling microbial syringol conversion through structure-guided protein engineering
por: Machovina, Melodie M., et al.
Publicado: (2019)

Muscle acetylcholine receptor conversion into chloride conductance at positive potentials by a single mutation
por: Cetin, Hakan, et al.
Publicado: (2019)

Local protein solvation drives direct down-conversion in phycobiliprotein PC645 via incoherent vibronic transport
por: Blau, Samuel M., et al.
Publicado: (2018)

Tracking the genome-wide outcomes of a transposable element burst over decades of amplification
por: Lu, Lu, et al.
Publicado: (2017)

Six6 and Six7 coordinately regulate expression of middle-wavelength opsins in zebrafish
por: Ogawa, Yohey, et al.
Publicado: (2019)

Multiple sensory neurons mediate starvation-dependent aversive navigation in Caenorhabditis elegans
por: Jang, Moon Sun, et al.
Publicado: (2019)

Regulation of inflammatory responses by dynamic subcellular localization of RNA-binding protein Arid5a
por: Higa, Mitsuru, et al.
Publicado: (2018)

Defective cortex glia plasma membrane structure underlies light-induced epilepsy in cpes mutants
por: Kunduri, Govind, et al.
Publicado: (2018)

Impaired hematopoiesis and leukemia development in mice with a conditional knock-in allele of a mutant splicing factor gene U2af1
por: Fei, Dennis Liang, et al.
Publicado: (2018)

Identification of cytokine-specific sensory neural signals by decoding murine vagus nerve activity
por: Zanos, Theodoros P., et al.
Publicado: (2018)

An ortholog of the Vasa intronic gene is required for small RNA-mediated translation repression in Chlamydomonas reinhardtii
por: Ma, Xinrong, et al.
Publicado: (2020)

Label-free chemical imaging flow cytometry by high-speed multicolor stimulated Raman scattering
por: Suzuki, Yuta, et al.
Publicado: (2019)

The CD4(−)CD8(−) MAIT cell subpopulation is a functionally distinct subset developmentally related to the main CD8(+) MAIT cell pool
por: Dias, Joana, et al.
Publicado: (2018)

Live births from artificial insemination of microfluidic-sorted bovine spermatozoa characterized by trajectories correlated with fertility
por: Nagata, Maria Portia B., et al.
Publicado: (2018)

Activation of unliganded FGF receptor by extracellular phosphate potentiates proteolytic protection of FGF23 by its O-glycosylation
por: Takashi, Yuichi, et al.
Publicado: (2019)

Partial maintenance of organ-specific epigenetic marks during plant asexual reproduction leads to heritable phenotypic variation
por: Wibowo, Anjar, et al.
Publicado: (2018)

Cardiomyocyte orientation modulated by the Numb family proteins–N-cadherin axis is essential for ventricular wall morphogenesis
por: Miao, Lianjie, et al.
Publicado: (2019)

Root-specific camalexin biosynthesis controls the plant growth-promoting effects of multiple bacterial strains
por: Koprivova, Anna, et al.
Publicado: (2019)

Balancing trade-offs between biotic and abiotic stress responses through leaf age-dependent variation in stress hormone cross-talk
por: Berens, Matthias L., et al.
Publicado: (2019)

Glia-derived exosomal miR-274 targets Sprouty in trachea and synaptic boutons to modulate growth and responses to hypoxia
por: Tsai, Yi-Wei, et al.
Publicado: (2019)

Live-cell analysis of endogenous GFP-RPB1 uncovers rapid turnover of initiating and promoter-paused RNA Polymerase II
por: Steurer, Barbara, et al.
Publicado: (2018)

Mutagenesis of odorant coreceptor Orco fully disrupts foraging but not oviposition behaviors in the hawkmoth Manduca sexta
por: Fandino, Richard A., et al.
Publicado: (2019)

Cryo-EM analysis of a feline coronavirus spike protein reveals a unique structure and camouflaging glycans
por: Yang, Tzu-Jing, et al.
Publicado: (2020)

Genomic and molecular characterization of preterm birth
por: Knijnenburg, Theo A., et al.
Publicado: (2019)

Defining the sizes of airborne particles that mediate influenza transmission in ferrets
por: Zhou, Jie, et al.
Publicado: (2018)

Redirection of SKN-1 abates the negative metabolic outcomes of a perceived pathogen infection
por: Nhan, James D., et al.
Publicado: (2019)

YES1 amplification is a mechanism of acquired resistance to EGFR inhibitors identified by transposon mutagenesis and clinical genomics
por: Fan, Pang-Dian, et al.
Publicado: (2018)

Global impacts of chromosomal imbalance on gene expression in Arabidopsis and other taxa
por: Hou, Jie, et al.
Publicado: (2018)

Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance
por: Kirkman, Laura A., et al.
Publicado: (2018)

Solenodon genome reveals convergent evolution of venom in eulipotyphlan mammals
por: Casewell, Nicholas R., et al.
Publicado: (2019)

Molecular blueprint of allosteric binding sites in a homologue of the agonist-binding domain of the α7 nicotinic acetylcholine receptor
por: Spurny, Radovan, et al.
Publicado: (2015)

Metabolic and trophic interactions modulate methane production by Arctic peat microbiota in response to warming
por: Tveit, Alexander Tøsdal, et al.
Publicado: (2015)

Regulation of age-related macular degeneration-like pathology by complement factor H
por: Toomey, Christopher B., et al.
Publicado: (2015)

Angiopoietin-like 4 is a potent angiogenic factor and a novel therapeutic target for patients with proliferative diabetic retinopathy
por: Babapoor-Farrokhran, Savalan, et al.
Publicado: (2015)

BDNF pro-peptide actions facilitate hippocampal LTD and are altered by the common BDNF polymorphism Val66Met
por: Mizui, Toshiyuki, et al.
Publicado: (2015)

Systematic transcriptome analysis reveals tumor-specific isoforms for ovarian cancer diagnosis and therapy
por: Barrett, Christian L., et al.
Publicado: (2015)

Reduced endogenous Ca(2+) buffering speeds active zone Ca(2+) signaling
por: Delvendahl, Igor, et al.
Publicado: (2015)

Paclitaxel-induced epithelial damage and ectopic MMP-13 expression promotes neurotoxicity in zebrafish
por: Lisse, Thomas S., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_cshd5v52isldgscvks41smf3ah