Evidence for bidirectional and trans-synaptic parasympathetic and sympathetic propagation of alpha-synuclein in rats

The conversion of endogenous alpha-synuclein (asyn) to pathological asyn-enriched aggregates is a hallmark of Parkinson’s disease (PD). These inclusions can be detected in the central and enteric nervous system (ENS). Moreover, gastrointestinal symptoms can appear up to 20 years before the diagnosis...

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Detalles Bibliográficos
Autores principales: Van Den Berge, Nathalie, Ferreira, Nelson, Gram, Hjalte, Mikkelsen, Trine Werenberg, Alstrup, Aage Kristian Olsen, Casadei, Nicolas, Tsung-Pin, Pai, Riess, Olaf, Nyengaard, Jens Randel, Tamgüney, Gültekin, Jensen, Poul Henning, Borghammer, Per
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2019
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778265/
https://www.ncbi.nlm.nih.gov/pubmed/31254094
http://dx.doi.org/10.1007/s00401-019-02040-w

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