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Ligand-induced IFNGR1 down-regulation calibrates myeloid cell IFNγ responsiveness

The type II IFN (IFNγ) enhances antimicrobial activity yet also drives expression of genes that amplify inflammatory responses. Hence, excessive IFNγ stimulation can be pathogenic. Here, we describe a previously unappreciated mechanism whereby IFNγ itself dampens myeloid cell activation. Staining of...

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Detalles Bibliográficos
Autores principales:	Crisler, William J, Eshleman, Emily M, Lenz, Laurel L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Life Science Alliance LLC 2019
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778285/ https://www.ncbi.nlm.nih.gov/pubmed/31585982 http://dx.doi.org/10.26508/lsa.201900447

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