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Snail and E-Cadherin Immunoexpression in Clear Cell Renal Cell Carcinoma

Renal cell clear cell carcinomas (ccRCC) represent 75% of the malignant renal neoplasias. A critical molecular characteristic in the epithelial-mesenchymal transition (EMT) is the loss of E-cadherin expression, as well as the epithelial-mesenchymal transcription factors, one of the most important of...

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Autores principales: ANDREIANA, BC, STEPAN, AE, MĂRGĂRITESCU, C, TĂISESCU, O, OSMAN, A, SIMIONESCU, C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medical University Publishing House Craiova 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778299/
https://www.ncbi.nlm.nih.gov/pubmed/31624646
http://dx.doi.org/10.12865/CHSJ.45.02.09
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author ANDREIANA, BC
STEPAN, AE
MĂRGĂRITESCU, C
TĂISESCU, O
OSMAN, A
SIMIONESCU, C
author_facet ANDREIANA, BC
STEPAN, AE
MĂRGĂRITESCU, C
TĂISESCU, O
OSMAN, A
SIMIONESCU, C
author_sort ANDREIANA, BC
collection PubMed
description Renal cell clear cell carcinomas (ccRCC) represent 75% of the malignant renal neoplasias. A critical molecular characteristic in the epithelial-mesenchymal transition (EMT) is the loss of E-cadherin expression, as well as the epithelial-mesenchymal transcription factors, one of the most important of which is Snail. In the current study, we analyzed the immunoexpression of the two markers in 46 cases of clear cell renal cell carcinomas, with reference to the most important prognosis histopathological factors. Our results indicated significant associations between the overexpression of Snail, under expression of E-cadherin and high Fuhrman grade. E-cadherin immunoexpression was high in incipient tumoral stages, and Snail was overexpressed in advanced tumoral stages of ccRCC. Our study supports the importance of this antibody panel in the prognosis of ccRCC.
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spelling pubmed-67782992019-10-17 Snail and E-Cadherin Immunoexpression in Clear Cell Renal Cell Carcinoma ANDREIANA, BC STEPAN, AE MĂRGĂRITESCU, C TĂISESCU, O OSMAN, A SIMIONESCU, C Curr Health Sci J Original Paper Renal cell clear cell carcinomas (ccRCC) represent 75% of the malignant renal neoplasias. A critical molecular characteristic in the epithelial-mesenchymal transition (EMT) is the loss of E-cadherin expression, as well as the epithelial-mesenchymal transcription factors, one of the most important of which is Snail. In the current study, we analyzed the immunoexpression of the two markers in 46 cases of clear cell renal cell carcinomas, with reference to the most important prognosis histopathological factors. Our results indicated significant associations between the overexpression of Snail, under expression of E-cadherin and high Fuhrman grade. E-cadherin immunoexpression was high in incipient tumoral stages, and Snail was overexpressed in advanced tumoral stages of ccRCC. Our study supports the importance of this antibody panel in the prognosis of ccRCC. Medical University Publishing House Craiova 2019 2019-06-30 /pmc/articles/PMC6778299/ /pubmed/31624646 http://dx.doi.org/10.12865/CHSJ.45.02.09 Text en Copyright © 2019, Medical University Publishing House Craiova http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an open-access article distributed under the terms of a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International Public License, which permits unrestricted use, adaptation, distribution and reproduction in any medium, non-commercially, provided the new creations are licensed under identical terms as the original work and the original work is properly cited.
spellingShingle Original Paper
ANDREIANA, BC
STEPAN, AE
MĂRGĂRITESCU, C
TĂISESCU, O
OSMAN, A
SIMIONESCU, C
Snail and E-Cadherin Immunoexpression in Clear Cell Renal Cell Carcinoma
title Snail and E-Cadherin Immunoexpression in Clear Cell Renal Cell Carcinoma
title_full Snail and E-Cadherin Immunoexpression in Clear Cell Renal Cell Carcinoma
title_fullStr Snail and E-Cadherin Immunoexpression in Clear Cell Renal Cell Carcinoma
title_full_unstemmed Snail and E-Cadherin Immunoexpression in Clear Cell Renal Cell Carcinoma
title_short Snail and E-Cadherin Immunoexpression in Clear Cell Renal Cell Carcinoma
title_sort snail and e-cadherin immunoexpression in clear cell renal cell carcinoma
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778299/
https://www.ncbi.nlm.nih.gov/pubmed/31624646
http://dx.doi.org/10.12865/CHSJ.45.02.09
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