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A Statistical Analysis of Risk Groups in Colorectal Cancer Patients

Colorectal cancer (CRC) is considered a major global health concern due to an increasing number of new cases and cancer-related deaths each year, strong link to dietary habits prevalent in middle and high-income countries and limited therapeutic options especially in locally-advanced and metastatic...

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Autores principales: FLORESCU-ŢENEA, RM, KAMAL, AM, MITRUŢ, P, MITRUŢ, R, ILIE, DS, NICOLAESCU, AC, MOGOANTĂ, L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medical University Publishing House Craiova 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778301/
https://www.ncbi.nlm.nih.gov/pubmed/31624645
http://dx.doi.org/10.12865/CHSJ.45.02.08
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author FLORESCU-ŢENEA, RM
KAMAL, AM
MITRUŢ, P
MITRUŢ, R
ILIE, DS
NICOLAESCU, AC
MOGOANTĂ, L
author_facet FLORESCU-ŢENEA, RM
KAMAL, AM
MITRUŢ, P
MITRUŢ, R
ILIE, DS
NICOLAESCU, AC
MOGOANTĂ, L
author_sort FLORESCU-ŢENEA, RM
collection PubMed
description Colorectal cancer (CRC) is considered a major global health concern due to an increasing number of new cases and cancer-related deaths each year, strong link to dietary habits prevalent in middle and high-income countries and limited therapeutic options especially in locally-advanced and metastatic settings. To counter this growing problem, the scientific community has strived to underpin the major molecular mechanisms behind the aggressive phenotype displayed by CRC and also develop new agents to selectively target and inhibit these core drivers. This evolution has allowed the separation of patients according to different risk groups in concordance with epidemiological parameters alongside novel biomarkers such as gene alterations, protein overexpression and aberrant signaling pathways. In this study we included 20 patients who underwent colonoscopy and were later received histopathologic confirmation of CRC. The statistical anamnestic data obtained from the patients (age, gender, home distribution, signs and symptoms) was corroborated with the results obtained from the histopathologic and immunohistochemical analysis of the samples obtained via colonoscopy. The average age was 63.8 years, the male: female ratio was 2.33 and the origin of 2/3 of the patients was urban and the most encountered symptoms were transit disorders (75%). In terms of colonoscopy results, the majority of tumors were found on the rectum (85%), 90% of tumors were adenocarcinomas, having a vegetant aspect in 60% of the cases and a moderate degree of differentiation in 50% of situations.
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spelling pubmed-67783012019-10-17 A Statistical Analysis of Risk Groups in Colorectal Cancer Patients FLORESCU-ŢENEA, RM KAMAL, AM MITRUŢ, P MITRUŢ, R ILIE, DS NICOLAESCU, AC MOGOANTĂ, L Curr Health Sci J Original Paper Colorectal cancer (CRC) is considered a major global health concern due to an increasing number of new cases and cancer-related deaths each year, strong link to dietary habits prevalent in middle and high-income countries and limited therapeutic options especially in locally-advanced and metastatic settings. To counter this growing problem, the scientific community has strived to underpin the major molecular mechanisms behind the aggressive phenotype displayed by CRC and also develop new agents to selectively target and inhibit these core drivers. This evolution has allowed the separation of patients according to different risk groups in concordance with epidemiological parameters alongside novel biomarkers such as gene alterations, protein overexpression and aberrant signaling pathways. In this study we included 20 patients who underwent colonoscopy and were later received histopathologic confirmation of CRC. The statistical anamnestic data obtained from the patients (age, gender, home distribution, signs and symptoms) was corroborated with the results obtained from the histopathologic and immunohistochemical analysis of the samples obtained via colonoscopy. The average age was 63.8 years, the male: female ratio was 2.33 and the origin of 2/3 of the patients was urban and the most encountered symptoms were transit disorders (75%). In terms of colonoscopy results, the majority of tumors were found on the rectum (85%), 90% of tumors were adenocarcinomas, having a vegetant aspect in 60% of the cases and a moderate degree of differentiation in 50% of situations. Medical University Publishing House Craiova 2019 2019-06-30 /pmc/articles/PMC6778301/ /pubmed/31624645 http://dx.doi.org/10.12865/CHSJ.45.02.08 Text en Copyright © 2019, Medical University Publishing House Craiova http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an open-access article distributed under the terms of a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International Public License, which permits unrestricted use, adaptation, distribution and reproduction in any medium, non-commercially, provided the new creations are licensed under identical terms as the original work and the original work is properly cited.
spellingShingle Original Paper
FLORESCU-ŢENEA, RM
KAMAL, AM
MITRUŢ, P
MITRUŢ, R
ILIE, DS
NICOLAESCU, AC
MOGOANTĂ, L
A Statistical Analysis of Risk Groups in Colorectal Cancer Patients
title A Statistical Analysis of Risk Groups in Colorectal Cancer Patients
title_full A Statistical Analysis of Risk Groups in Colorectal Cancer Patients
title_fullStr A Statistical Analysis of Risk Groups in Colorectal Cancer Patients
title_full_unstemmed A Statistical Analysis of Risk Groups in Colorectal Cancer Patients
title_short A Statistical Analysis of Risk Groups in Colorectal Cancer Patients
title_sort statistical analysis of risk groups in colorectal cancer patients
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778301/
https://www.ncbi.nlm.nih.gov/pubmed/31624645
http://dx.doi.org/10.12865/CHSJ.45.02.08
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