Terminal Effector CD8 T Cells Defined by an IKZF2(+)IL-7R(−) Transcriptional Signature Express FcγRIIIA, Expand in HIV Infection, and Mediate Potent HIV-Specific Antibody-Dependent Cellular Cytotoxicity

HIV-1 infection expands large populations of late-stage differentiated CD8 T cells that may persist long after viral escape from TCR recognition. In this study, we investigated whether such CD8 T cell populations can perform unconventional innate-like antiviral effector functions. Chronic untreated...

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Detalles Bibliográficos
Autores principales: Naluyima, Prossy, Lal, Kerri G., Costanzo, Margaret C., Kijak, Gustavo H., Gonzalez, Veronica D., Blom, Kim, Eller, Leigh Anne, Creegan, Matthew, Hong, Ting, Kim, Dohoon, Quinn, Thomas C., Björkström, Niklas K., Ljunggren, Hans-Gustaf, Serwadda, David, Katabira, Elly T., Sewankambo, Nelson K., Gray, Ronald H., Baeten, Jared M., Michael, Nelson L., Wabwire-Mangen, Fred, Robb, Merlin L., Bolton, Diane L., Sandberg, Johan K., Eller, Michael A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AAI 2019
Materias:
Infectious Disease and Host Response
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778306/
https://www.ncbi.nlm.nih.gov/pubmed/31519862
http://dx.doi.org/10.4049/jimmunol.1900422

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