Impact of Tenofovir-Based Pre-exposure Prophylaxis on Biomarkers of Bone Formation, Bone Resorption, and Bone Mineral Metabolism in HIV-Negative Adults

BACKGROUND: Pre-exposure prophylaxis (PrEP) with emtricitabine (FTC)/tenofovir disoproxil fumarate (TDF) reduces the risk of HIV seroconversion but may promote bone mineral density (BMD) decline. The mechanisms of BMD decline with FTC/TDF remain unclear, and studies in HIV-positive individuals have...

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Detalles Bibliográficos
Autores principales: Nickolas, Thomas L, Yin, Michael T, Hong, Ting, Mugwanya, Kenneth K, Branch, Andrea D, Heffron, Renee, Ramalho, Janaina, Nandakumar, Renu, Dworakowski, Elzbieta, Wanga, Valentine, Mugo, Nelly R, Ronald, Allan, Celum, Connie, Donnell, Deborah, Baeten, Jared M, Wyatt, Christina M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Major Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778426/
https://www.ncbi.nlm.nih.gov/pubmed/31660332
http://dx.doi.org/10.1093/ofid/ofz338

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