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A Compendium of Promoter-Centered Long-Range Chromatin Interactions in the Human Genome
A large number of putative cis-regulatory sequences have been annotated in the human genome, but the genes they control remain poorly defined. To bridge this gap, we generate maps of long-range chromatin interactions centered on 18,943 well-annotated promoters for protein-coding genes in 27 human ce...
| Autores principales: | , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778519/ https://www.ncbi.nlm.nih.gov/pubmed/31501517 http://dx.doi.org/10.1038/s41588-019-0494-8 |
| _version_ | 1783456773618794496 |
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| author | Jung, Inkyung Schmitt, Anthony Diao, Yarui Lee, Andrew J. Liu, Tristin Yang, Dongchan Tan, Catherine Eom, Junghyun Chan, Marilynn Chee, Sora Chiang, Zachary Kim, Changyoun Masliah, Eliezer Barr, Cathy L. Li, Bin Kuan, Samantha Kim, Dongsup Ren, Bing |
| author_facet | Jung, Inkyung Schmitt, Anthony Diao, Yarui Lee, Andrew J. Liu, Tristin Yang, Dongchan Tan, Catherine Eom, Junghyun Chan, Marilynn Chee, Sora Chiang, Zachary Kim, Changyoun Masliah, Eliezer Barr, Cathy L. Li, Bin Kuan, Samantha Kim, Dongsup Ren, Bing |
| author_sort | Jung, Inkyung |
| collection | PubMed |
| description | A large number of putative cis-regulatory sequences have been annotated in the human genome, but the genes they control remain poorly defined. To bridge this gap, we generate maps of long-range chromatin interactions centered on 18,943 well-annotated promoters for protein-coding genes in 27 human cell/tissue types. We use this information to infer the target genes of 70,329 candidate regulatory elements, and suggest potential regulatory function for 27,325 non-coding sequence variants associated with 2,117 physiological traits and diseases. Integrative analysis of these promoter-centered interactome maps reveals widespread enhancer-like promoters involved in gene regulation and common molecular pathways underlying distinct groups of human traits and diseases. |
| format | Online Article Text |
| id | pubmed-6778519 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2019 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-67785192020-03-09 A Compendium of Promoter-Centered Long-Range Chromatin Interactions in the Human Genome Jung, Inkyung Schmitt, Anthony Diao, Yarui Lee, Andrew J. Liu, Tristin Yang, Dongchan Tan, Catherine Eom, Junghyun Chan, Marilynn Chee, Sora Chiang, Zachary Kim, Changyoun Masliah, Eliezer Barr, Cathy L. Li, Bin Kuan, Samantha Kim, Dongsup Ren, Bing Nat Genet Article A large number of putative cis-regulatory sequences have been annotated in the human genome, but the genes they control remain poorly defined. To bridge this gap, we generate maps of long-range chromatin interactions centered on 18,943 well-annotated promoters for protein-coding genes in 27 human cell/tissue types. We use this information to infer the target genes of 70,329 candidate regulatory elements, and suggest potential regulatory function for 27,325 non-coding sequence variants associated with 2,117 physiological traits and diseases. Integrative analysis of these promoter-centered interactome maps reveals widespread enhancer-like promoters involved in gene regulation and common molecular pathways underlying distinct groups of human traits and diseases. 2019-09-09 2019-10 /pmc/articles/PMC6778519/ /pubmed/31501517 http://dx.doi.org/10.1038/s41588-019-0494-8 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Jung, Inkyung Schmitt, Anthony Diao, Yarui Lee, Andrew J. Liu, Tristin Yang, Dongchan Tan, Catherine Eom, Junghyun Chan, Marilynn Chee, Sora Chiang, Zachary Kim, Changyoun Masliah, Eliezer Barr, Cathy L. Li, Bin Kuan, Samantha Kim, Dongsup Ren, Bing A Compendium of Promoter-Centered Long-Range Chromatin Interactions in the Human Genome |
| title | A Compendium of Promoter-Centered Long-Range Chromatin Interactions
in the Human Genome |
| title_full | A Compendium of Promoter-Centered Long-Range Chromatin Interactions
in the Human Genome |
| title_fullStr | A Compendium of Promoter-Centered Long-Range Chromatin Interactions
in the Human Genome |
| title_full_unstemmed | A Compendium of Promoter-Centered Long-Range Chromatin Interactions
in the Human Genome |
| title_short | A Compendium of Promoter-Centered Long-Range Chromatin Interactions
in the Human Genome |
| title_sort | compendium of promoter-centered long-range chromatin interactions
in the human genome |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778519/ https://www.ncbi.nlm.nih.gov/pubmed/31501517 http://dx.doi.org/10.1038/s41588-019-0494-8 |
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