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Receptor density pattern confirms and enhances the anatomic-functional features of the macaque superior parietal lobule areas
The macaque monkey superior parietal lobule (SPL) is part of a neuronal network involved in the integration of information from visual and somatosensory cortical areas for execution of reaching and grasping movements. We applied quantitative in vitro receptor autoradiography to analyse the distribut...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778536/ https://www.ncbi.nlm.nih.gov/pubmed/31392403 http://dx.doi.org/10.1007/s00429-019-01930-9 |
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author | Impieri, Daniele Zilles, Karl Niu, Meiqi Rapan, Lucija Schubert, Nicole Galletti, Claudio Palomero-Gallagher, Nicola |
author_facet | Impieri, Daniele Zilles, Karl Niu, Meiqi Rapan, Lucija Schubert, Nicole Galletti, Claudio Palomero-Gallagher, Nicola |
author_sort | Impieri, Daniele |
collection | PubMed |
description | The macaque monkey superior parietal lobule (SPL) is part of a neuronal network involved in the integration of information from visual and somatosensory cortical areas for execution of reaching and grasping movements. We applied quantitative in vitro receptor autoradiography to analyse the distribution patterns of 15 different receptors for glutamate, GABA, acetylcholine, serotonin, dopamine, and adenosine in the SPL of three adult male Macaca fascicularis monkeys. For each area, mean (averaged over all cortical layers) receptor densities were visualized as a receptor fingerprint of that area. Multivariate analyses were conducted to detect clusters of areas according to the degree of (dis)similarity of their receptor organization. Differences in regional and laminar receptor distributions confirm the location and extent of areas V6, V6Av, V6Ad, PEc, PEci, and PGm as found in cytoarchitectonic and functional studies, but also enable the definition of three subdivisions within area PE. Receptor densities are higher in supra- than in infragranular layers, with the exception of kainate, M(2), and adenosine receptors. Glutamate and GABAergic receptors are the most expressed in all areas analysed. Hierarchical cluster analyses demonstrate that SPL areas are organized in two groups, an organization that corresponds to the visual or sensory-motor characteristics of those areas. Finally, based on present results and in the framework of our current understanding of the structural and functional organization of the primate SPL, we propose a novel pattern of homologies between human and macaque SPL areas. |
format | Online Article Text |
id | pubmed-6778536 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-67785362019-10-17 Receptor density pattern confirms and enhances the anatomic-functional features of the macaque superior parietal lobule areas Impieri, Daniele Zilles, Karl Niu, Meiqi Rapan, Lucija Schubert, Nicole Galletti, Claudio Palomero-Gallagher, Nicola Brain Struct Funct Original Article The macaque monkey superior parietal lobule (SPL) is part of a neuronal network involved in the integration of information from visual and somatosensory cortical areas for execution of reaching and grasping movements. We applied quantitative in vitro receptor autoradiography to analyse the distribution patterns of 15 different receptors for glutamate, GABA, acetylcholine, serotonin, dopamine, and adenosine in the SPL of three adult male Macaca fascicularis monkeys. For each area, mean (averaged over all cortical layers) receptor densities were visualized as a receptor fingerprint of that area. Multivariate analyses were conducted to detect clusters of areas according to the degree of (dis)similarity of their receptor organization. Differences in regional and laminar receptor distributions confirm the location and extent of areas V6, V6Av, V6Ad, PEc, PEci, and PGm as found in cytoarchitectonic and functional studies, but also enable the definition of three subdivisions within area PE. Receptor densities are higher in supra- than in infragranular layers, with the exception of kainate, M(2), and adenosine receptors. Glutamate and GABAergic receptors are the most expressed in all areas analysed. Hierarchical cluster analyses demonstrate that SPL areas are organized in two groups, an organization that corresponds to the visual or sensory-motor characteristics of those areas. Finally, based on present results and in the framework of our current understanding of the structural and functional organization of the primate SPL, we propose a novel pattern of homologies between human and macaque SPL areas. Springer Berlin Heidelberg 2019-08-07 2019 /pmc/articles/PMC6778536/ /pubmed/31392403 http://dx.doi.org/10.1007/s00429-019-01930-9 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Original Article Impieri, Daniele Zilles, Karl Niu, Meiqi Rapan, Lucija Schubert, Nicole Galletti, Claudio Palomero-Gallagher, Nicola Receptor density pattern confirms and enhances the anatomic-functional features of the macaque superior parietal lobule areas |
title | Receptor density pattern confirms and enhances the anatomic-functional features of the macaque superior parietal lobule areas |
title_full | Receptor density pattern confirms and enhances the anatomic-functional features of the macaque superior parietal lobule areas |
title_fullStr | Receptor density pattern confirms and enhances the anatomic-functional features of the macaque superior parietal lobule areas |
title_full_unstemmed | Receptor density pattern confirms and enhances the anatomic-functional features of the macaque superior parietal lobule areas |
title_short | Receptor density pattern confirms and enhances the anatomic-functional features of the macaque superior parietal lobule areas |
title_sort | receptor density pattern confirms and enhances the anatomic-functional features of the macaque superior parietal lobule areas |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778536/ https://www.ncbi.nlm.nih.gov/pubmed/31392403 http://dx.doi.org/10.1007/s00429-019-01930-9 |
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