A Case Series of Severe Hyperammonemia Encephalopathy Related to Valproate: Can Antipsychotics Increase the Risk?

Valproate-induced hyperammonemia is a common side effect of valproate, which may occur either without any symptoms or may rarely cause symptoms of encephalopathy. Different risk factors have been defined for this side effect, including some nutritional deficiencies and polypharmacy (eg, other antico...

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Autores principales: Davoudi-Monfared, Effat, Radmehr, Mojan, Ghaeli, Padideh, Mousavi, Maryam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Psychiatry & Psychology Research Center, Tehran University of Medical Sciences 2019
Materias:
Case Series
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778604/
https://www.ncbi.nlm.nih.gov/pubmed/31598129
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author Davoudi-Monfared, Effat
Radmehr, Mojan
Ghaeli, Padideh
Mousavi, Maryam
author_facet Davoudi-Monfared, Effat
Radmehr, Mojan
Ghaeli, Padideh
Mousavi, Maryam
author_sort Davoudi-Monfared, Effat
collection PubMed
description Valproate-induced hyperammonemia is a common side effect of valproate, which may occur either without any symptoms or may rarely cause symptoms of encephalopathy. Different risk factors have been defined for this side effect, including some nutritional deficiencies and polypharmacy (eg, other anticonvulsants). Three cases with psychiatric disorder who showed symptoms of severe hyperammonemia encephalopathy and had taken valproate with antipsychotics, especially risperidone, are presented here. In all cases, the symptoms were improved by discontinuation of valproate. Administration of antipsychotic may be considered as a risk factor for hyperammonemic encephalopathy related to valproate, specifically in some prone populations.
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spelling pubmed-67786042019-10-09 A Case Series of Severe Hyperammonemia Encephalopathy Related to Valproate: Can Antipsychotics Increase the Risk? Davoudi-Monfared, Effat Radmehr, Mojan Ghaeli, Padideh Mousavi, Maryam Iran J Psychiatry Case Series Valproate-induced hyperammonemia is a common side effect of valproate, which may occur either without any symptoms or may rarely cause symptoms of encephalopathy. Different risk factors have been defined for this side effect, including some nutritional deficiencies and polypharmacy (eg, other anticonvulsants). Three cases with psychiatric disorder who showed symptoms of severe hyperammonemia encephalopathy and had taken valproate with antipsychotics, especially risperidone, are presented here. In all cases, the symptoms were improved by discontinuation of valproate. Administration of antipsychotic may be considered as a risk factor for hyperammonemic encephalopathy related to valproate, specifically in some prone populations. Psychiatry & Psychology Research Center, Tehran University of Medical Sciences 2019-07 /pmc/articles/PMC6778604/ /pubmed/31598129 Text en Copyright © Psychiatry & Psychology Research Center, Tehran University of Medical Sciences This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Series
Davoudi-Monfared, Effat
Radmehr, Mojan
Ghaeli, Padideh
Mousavi, Maryam
A Case Series of Severe Hyperammonemia Encephalopathy Related to Valproate: Can Antipsychotics Increase the Risk?
title A Case Series of Severe Hyperammonemia Encephalopathy Related to Valproate: Can Antipsychotics Increase the Risk?
title_full A Case Series of Severe Hyperammonemia Encephalopathy Related to Valproate: Can Antipsychotics Increase the Risk?
title_fullStr A Case Series of Severe Hyperammonemia Encephalopathy Related to Valproate: Can Antipsychotics Increase the Risk?
title_full_unstemmed A Case Series of Severe Hyperammonemia Encephalopathy Related to Valproate: Can Antipsychotics Increase the Risk?
title_short A Case Series of Severe Hyperammonemia Encephalopathy Related to Valproate: Can Antipsychotics Increase the Risk?
title_sort case series of severe hyperammonemia encephalopathy related to valproate: can antipsychotics increase the risk?
topic Case Series
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778604/
https://www.ncbi.nlm.nih.gov/pubmed/31598129
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