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Neutrophil to Lymphocyte and Platelet to Lymphocyte Ratios in Normal Tension Glaucoma

Normal tension glaucoma (NTG) is a subtype of glaucoma that occurs at relatively low intraocular pressure levels and results in progressive optic neuropathy. Previous studies display some abnormal immune activity against the optic nerve. Neutrophil to lymphocyte (NLR) and platelet to lymphocyte rati...

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Autores principales: Atalay, Kursat, Erdogan Kaldirim, Havva, Kirgiz, Ahmet, Asik Nacaroglu, Senay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medical Hypothesis, Discovery & Innovation Ophthalmology 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778680/
https://www.ncbi.nlm.nih.gov/pubmed/31788489
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author Atalay, Kursat
Erdogan Kaldirim, Havva
Kirgiz, Ahmet
Asik Nacaroglu, Senay
author_facet Atalay, Kursat
Erdogan Kaldirim, Havva
Kirgiz, Ahmet
Asik Nacaroglu, Senay
author_sort Atalay, Kursat
collection PubMed
description Normal tension glaucoma (NTG) is a subtype of glaucoma that occurs at relatively low intraocular pressure levels and results in progressive optic neuropathy. Previous studies display some abnormal immune activity against the optic nerve. Neutrophil to lymphocyte (NLR) and platelet to lymphocyte ratios (PLR) are novel markers for inflammation. Here we evaluated the NLR, PLR, Creactive protein (CRP) and erythrocyte sedimentation rate (ESR) levels in NTG. NLR and PLR were resulted by dividing neutrophil and platelet counts to lymphocyte count respectively. Patients with a history of diabetes mellitus, chronic renal failure, rheumatologic disease, anemia, cancer, cigarette smoking, myocardial infarction and a febrile illness within one month of sampling were excluded from the investigation. In total, the blood samples of 28 NTG and 27control patients were analyzed for the study. There were 11 female (40.7%) and 16 male patients (59.3%) in the control group. The NTG group contained 15 (53.6%) female and 13 (46.4%) male patients. All of the NLR, PLR, ESR and CRP, values of NTG patients were not statistically different from the control group (P = 0.07, P = 0.64, P = 0.17, and P = 0.44 respectively). Although previous studies have shown significant differences in NLR and PLR levels in other types of glaucoma, we did not find any significant difference in NTG subjects. Our early report may give insight into the differential diagnosis of NTG.
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spelling pubmed-67786802019-12-01 Neutrophil to Lymphocyte and Platelet to Lymphocyte Ratios in Normal Tension Glaucoma Atalay, Kursat Erdogan Kaldirim, Havva Kirgiz, Ahmet Asik Nacaroglu, Senay Med Hypothesis Discov Innov Ophthalmol Original Article Normal tension glaucoma (NTG) is a subtype of glaucoma that occurs at relatively low intraocular pressure levels and results in progressive optic neuropathy. Previous studies display some abnormal immune activity against the optic nerve. Neutrophil to lymphocyte (NLR) and platelet to lymphocyte ratios (PLR) are novel markers for inflammation. Here we evaluated the NLR, PLR, Creactive protein (CRP) and erythrocyte sedimentation rate (ESR) levels in NTG. NLR and PLR were resulted by dividing neutrophil and platelet counts to lymphocyte count respectively. Patients with a history of diabetes mellitus, chronic renal failure, rheumatologic disease, anemia, cancer, cigarette smoking, myocardial infarction and a febrile illness within one month of sampling were excluded from the investigation. In total, the blood samples of 28 NTG and 27control patients were analyzed for the study. There were 11 female (40.7%) and 16 male patients (59.3%) in the control group. The NTG group contained 15 (53.6%) female and 13 (46.4%) male patients. All of the NLR, PLR, ESR and CRP, values of NTG patients were not statistically different from the control group (P = 0.07, P = 0.64, P = 0.17, and P = 0.44 respectively). Although previous studies have shown significant differences in NLR and PLR levels in other types of glaucoma, we did not find any significant difference in NTG subjects. Our early report may give insight into the differential diagnosis of NTG. Medical Hypothesis, Discovery & Innovation Ophthalmology 2019 2019-10-01 /pmc/articles/PMC6778680/ /pubmed/31788489 Text en © 2019, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial 4.0 International License (http://creativecommons.org/licenses/by/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
spellingShingle Original Article
Atalay, Kursat
Erdogan Kaldirim, Havva
Kirgiz, Ahmet
Asik Nacaroglu, Senay
Neutrophil to Lymphocyte and Platelet to Lymphocyte Ratios in Normal Tension Glaucoma
title Neutrophil to Lymphocyte and Platelet to Lymphocyte Ratios in Normal Tension Glaucoma
title_full Neutrophil to Lymphocyte and Platelet to Lymphocyte Ratios in Normal Tension Glaucoma
title_fullStr Neutrophil to Lymphocyte and Platelet to Lymphocyte Ratios in Normal Tension Glaucoma
title_full_unstemmed Neutrophil to Lymphocyte and Platelet to Lymphocyte Ratios in Normal Tension Glaucoma
title_short Neutrophil to Lymphocyte and Platelet to Lymphocyte Ratios in Normal Tension Glaucoma
title_sort neutrophil to lymphocyte and platelet to lymphocyte ratios in normal tension glaucoma
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778680/
https://www.ncbi.nlm.nih.gov/pubmed/31788489
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