A New Antisense Phosphoryl Guanidine Oligo-2′-O-Methylribonucleotide Penetrates Into Intracellular Mycobacteria and Suppresses Target Gene Expression

The worldwide spread of multidrug-resistant Mycobacterium tuberculosis strains prompted the development of new strategies to combat tuberculosis, one of which is antisense therapy based on targeting bacterial mRNA by oligonucleotide derivatives. However, the main limitation of antisense antibacteria...

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Detalles Bibliográficos
Autores principales: Skvortsova, Yulia V., Salina, Elena G., Burakova, Ekaterina A., Bychenko, Oksana S., Stetsenko, Dmitry A., Azhikina, Tatyana L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778816/
https://www.ncbi.nlm.nih.gov/pubmed/31632266
http://dx.doi.org/10.3389/fphar.2019.01049

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778816/
https://www.ncbi.nlm.nih.gov/pubmed/31632266
http://dx.doi.org/10.3389/fphar.2019.01049

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