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Structural comparison of protiated, H/D-exchanged and deuterated human carbonic anhydrase IX

Human carbonic anhydrase IX (CA IX) expression is upregulated in hypoxic solid tumours, promoting cell survival and metastasis. This observation has made CA IX a target for the development of CA isoform-selective inhibitors. To enable structural studies of CA IX–inhibitor complexes using X-ray and n...

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Detalles Bibliográficos
Autores principales:	Koruza, K., Lafumat, B., Nyblom, M., Mahon, B. P., Knecht, W., McKenna, R., Fisher, S. Z.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	International Union of Crystallography 2019
Materias:	Research Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778848/ https://www.ncbi.nlm.nih.gov/pubmed/31588921 http://dx.doi.org/10.1107/S2059798319010027

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