Abnormally Elevated Follicle-Stimulating Hormone (FSH) Level in an Infertile Woman

We report a case of 33-year-old woman with a 4-year primary infertility. A high isolated follicle-stimulating hormone (FSH) level was conflicting with the clinical situation and with other hormonal markers which were in favor of polycystic ovarian syndrome. We followed a strategy used to identify im...

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Detalles Bibliográficos
Autores principales: Catteau, Aurore, Bach-Ngohou, Kalyane, Blin, Justine, Barrière, Paul, Fréour, Thomas, Masson, Damien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778895/
https://www.ncbi.nlm.nih.gov/pubmed/31662912
http://dx.doi.org/10.1155/2019/3071649
Descripción
Sumario:We report a case of 33-year-old woman with a 4-year primary infertility. A high isolated follicle-stimulating hormone (FSH) level was conflicting with the clinical situation and with other hormonal markers which were in favor of polycystic ovarian syndrome. We followed a strategy used to identify immune complexes involving FSH. The PEG precipitation test revealed that the high FSH level was almost exclusively due to the presence of autoimmune FSH immunoglobulin complex (macro-FSH). The profile obtained by gel filtration chromatography confirmed the presence of an FSH-immunoglobulin complex. Such immunological dysregulation could be explored in cases of unexplained infertility and recurrent IVF failure.

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