Abnormally Elevated Follicle-Stimulating Hormone (FSH) Level in an Infertile Woman

We report a case of 33-year-old woman with a 4-year primary infertility. A high isolated follicle-stimulating hormone (FSH) level was conflicting with the clinical situation and with other hormonal markers which were in favor of polycystic ovarian syndrome. We followed a strategy used to identify im...

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Detalles Bibliográficos
Autores principales: Catteau, Aurore, Bach-Ngohou, Kalyane, Blin, Justine, Barrière, Paul, Fréour, Thomas, Masson, Damien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778895/
https://www.ncbi.nlm.nih.gov/pubmed/31662912
http://dx.doi.org/10.1155/2019/3071649
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author Catteau, Aurore
Bach-Ngohou, Kalyane
Blin, Justine
Barrière, Paul
Fréour, Thomas
Masson, Damien
author_facet Catteau, Aurore
Bach-Ngohou, Kalyane
Blin, Justine
Barrière, Paul
Fréour, Thomas
Masson, Damien
author_sort Catteau, Aurore
collection PubMed
description We report a case of 33-year-old woman with a 4-year primary infertility. A high isolated follicle-stimulating hormone (FSH) level was conflicting with the clinical situation and with other hormonal markers which were in favor of polycystic ovarian syndrome. We followed a strategy used to identify immune complexes involving FSH. The PEG precipitation test revealed that the high FSH level was almost exclusively due to the presence of autoimmune FSH immunoglobulin complex (macro-FSH). The profile obtained by gel filtration chromatography confirmed the presence of an FSH-immunoglobulin complex. Such immunological dysregulation could be explored in cases of unexplained infertility and recurrent IVF failure.
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spelling pubmed-67788952019-10-29 Abnormally Elevated Follicle-Stimulating Hormone (FSH) Level in an Infertile Woman Catteau, Aurore Bach-Ngohou, Kalyane Blin, Justine Barrière, Paul Fréour, Thomas Masson, Damien Case Rep Endocrinol Case Report We report a case of 33-year-old woman with a 4-year primary infertility. A high isolated follicle-stimulating hormone (FSH) level was conflicting with the clinical situation and with other hormonal markers which were in favor of polycystic ovarian syndrome. We followed a strategy used to identify immune complexes involving FSH. The PEG precipitation test revealed that the high FSH level was almost exclusively due to the presence of autoimmune FSH immunoglobulin complex (macro-FSH). The profile obtained by gel filtration chromatography confirmed the presence of an FSH-immunoglobulin complex. Such immunological dysregulation could be explored in cases of unexplained infertility and recurrent IVF failure. Hindawi 2019-09-22 /pmc/articles/PMC6778895/ /pubmed/31662912 http://dx.doi.org/10.1155/2019/3071649 Text en Copyright © 2019 Aurore Catteau et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Catteau, Aurore
Bach-Ngohou, Kalyane
Blin, Justine
Barrière, Paul
Fréour, Thomas
Masson, Damien
Abnormally Elevated Follicle-Stimulating Hormone (FSH) Level in an Infertile Woman
title Abnormally Elevated Follicle-Stimulating Hormone (FSH) Level in an Infertile Woman
title_full Abnormally Elevated Follicle-Stimulating Hormone (FSH) Level in an Infertile Woman
title_fullStr Abnormally Elevated Follicle-Stimulating Hormone (FSH) Level in an Infertile Woman
title_full_unstemmed Abnormally Elevated Follicle-Stimulating Hormone (FSH) Level in an Infertile Woman
title_short Abnormally Elevated Follicle-Stimulating Hormone (FSH) Level in an Infertile Woman
title_sort abnormally elevated follicle-stimulating hormone (fsh) level in an infertile woman
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778895/
https://www.ncbi.nlm.nih.gov/pubmed/31662912
http://dx.doi.org/10.1155/2019/3071649
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