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Serum visfatin level is associated with complexity of coronary artery disease in patients with stable angina pectoris

BACKGROUND: Visfatin is an adipokine that plays a role in the inflammatory process of atherosclerosis. This study aimed to investigate whether adipokine is associated with the extent of stable coronary artery disease (CAD). METHODS: The study population included 110 patients who underwent elective c...

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Autores principales: Duman, Hakan, Özyıldız, Ali Gökhan, Bahçeci, İlkay, Duman, Handan, Uslu, Abdulkadir, Ergül, Elif
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778987/
https://www.ncbi.nlm.nih.gov/pubmed/31588856
http://dx.doi.org/10.1177/1753944719880448
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author Duman, Hakan
Özyıldız, Ali Gökhan
Bahçeci, İlkay
Duman, Handan
Uslu, Abdulkadir
Ergül, Elif
author_facet Duman, Hakan
Özyıldız, Ali Gökhan
Bahçeci, İlkay
Duman, Handan
Uslu, Abdulkadir
Ergül, Elif
author_sort Duman, Hakan
collection PubMed
description BACKGROUND: Visfatin is an adipokine that plays a role in the inflammatory process of atherosclerosis. This study aimed to investigate whether adipokine is associated with the extent of stable coronary artery disease (CAD). METHODS: The study population included 110 patients who underwent elective coronary angiography (CAG) due to stable angina pectoris. The severity of CAD was assessed by the ‘Synergy Between Percutaneous Coronary Intervention With TAXUS and Cardiac Surgery (SYNTAX)’ score. We evaluated patients in two groups: group 1 with a SYNTAX score <22 (low) and group 2 with a SYNTAX score ⩾22 (intermediate to high). RESULTS: Serum visfatin (8.6 ± 4.2 ng/ml versus 13.4 ± 5.2 ng/ml, p < 0.001) and serum C-reactive protein (CRP) levels [0.46 (0.25–0.77) mg/dl versus 0.71 (0.32–1.10) mg/dl, p < 0.001] were lower in group 1. A positive significant correlation was found between serum visfatin level and SYNTAX score (r = 0.559, p < 0.001). In a multivariate logistic regression analysis, visfatin [odds ratio (OR) 1.22, 95% confidence interval (CI) 1.10–1.36; p < 0.001], CRP (OR 6.22, 95% CI 1.70–22.7; p = 0.006), and diabetes mellitus (OR 3.83, 95% CI 1.10–13.2; p = 0.034) were found to be independent predictors of SYNTAX score. CONCLUSIONS: Serum visfatin level was positively correlated with CAD severity in patients with high SYNTAX score. Serum visfatin level can be a useful biomarker for predicting high SYNTAX scores in patients with angina pectoris undergoing CAG.
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spelling pubmed-67789872019-10-18 Serum visfatin level is associated with complexity of coronary artery disease in patients with stable angina pectoris Duman, Hakan Özyıldız, Ali Gökhan Bahçeci, İlkay Duman, Handan Uslu, Abdulkadir Ergül, Elif Ther Adv Cardiovasc Dis Original Research BACKGROUND: Visfatin is an adipokine that plays a role in the inflammatory process of atherosclerosis. This study aimed to investigate whether adipokine is associated with the extent of stable coronary artery disease (CAD). METHODS: The study population included 110 patients who underwent elective coronary angiography (CAG) due to stable angina pectoris. The severity of CAD was assessed by the ‘Synergy Between Percutaneous Coronary Intervention With TAXUS and Cardiac Surgery (SYNTAX)’ score. We evaluated patients in two groups: group 1 with a SYNTAX score <22 (low) and group 2 with a SYNTAX score ⩾22 (intermediate to high). RESULTS: Serum visfatin (8.6 ± 4.2 ng/ml versus 13.4 ± 5.2 ng/ml, p < 0.001) and serum C-reactive protein (CRP) levels [0.46 (0.25–0.77) mg/dl versus 0.71 (0.32–1.10) mg/dl, p < 0.001] were lower in group 1. A positive significant correlation was found between serum visfatin level and SYNTAX score (r = 0.559, p < 0.001). In a multivariate logistic regression analysis, visfatin [odds ratio (OR) 1.22, 95% confidence interval (CI) 1.10–1.36; p < 0.001], CRP (OR 6.22, 95% CI 1.70–22.7; p = 0.006), and diabetes mellitus (OR 3.83, 95% CI 1.10–13.2; p = 0.034) were found to be independent predictors of SYNTAX score. CONCLUSIONS: Serum visfatin level was positively correlated with CAD severity in patients with high SYNTAX score. Serum visfatin level can be a useful biomarker for predicting high SYNTAX scores in patients with angina pectoris undergoing CAG. SAGE Publications 2019-10-05 /pmc/articles/PMC6778987/ /pubmed/31588856 http://dx.doi.org/10.1177/1753944719880448 Text en © The Author(s), 2019 http://www.creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Research
Duman, Hakan
Özyıldız, Ali Gökhan
Bahçeci, İlkay
Duman, Handan
Uslu, Abdulkadir
Ergül, Elif
Serum visfatin level is associated with complexity of coronary artery disease in patients with stable angina pectoris
title Serum visfatin level is associated with complexity of coronary artery disease in patients with stable angina pectoris
title_full Serum visfatin level is associated with complexity of coronary artery disease in patients with stable angina pectoris
title_fullStr Serum visfatin level is associated with complexity of coronary artery disease in patients with stable angina pectoris
title_full_unstemmed Serum visfatin level is associated with complexity of coronary artery disease in patients with stable angina pectoris
title_short Serum visfatin level is associated with complexity of coronary artery disease in patients with stable angina pectoris
title_sort serum visfatin level is associated with complexity of coronary artery disease in patients with stable angina pectoris
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778987/
https://www.ncbi.nlm.nih.gov/pubmed/31588856
http://dx.doi.org/10.1177/1753944719880448
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