Inhibition of histone deacetylase 2 reduces MDM2 expression and reduces tumor growth in dedifferentiated liposarcoma

Dedifferentiated liposarcoma (DDLPS) is a highly morbid mesenchymal tumor characterized and driven by genomic amplification of the MDM2 gene. Direct inhibition of MDM2 has shown promise pre-clinically, but has yet to be validated in clinical trials. Early in vitro studies have demonstrated that pan-...

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Detalles Bibliográficos
Autores principales: Seligson, Nathan D., Stets, Colin W., Demoret, Bryce W., Awasthi, Achal, Grosenbacher, Nicholas, Shakya, Reena, Hays, John L., Chen, James L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779286/
https://www.ncbi.nlm.nih.gov/pubmed/31620242
http://dx.doi.org/10.18632/oncotarget.27144

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779286/
https://www.ncbi.nlm.nih.gov/pubmed/31620242
http://dx.doi.org/10.18632/oncotarget.27144

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