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Health-Related Quality of Life in Children With Congenital Hyperinsulinism
Background: Quality of life (QoL) has not been studied in patients with congenital hyperinsulinism (CHI). Objectives: To examine whether the health-related quality of life (HRQoL) is worsened in patients with persistent or transient CHI. Methods: We studied HRQoL of 65 children with CHI aged 3–17 ye...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779698/ https://www.ncbi.nlm.nih.gov/pubmed/31632349 http://dx.doi.org/10.3389/fendo.2019.00670 |
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author | Männistö, Jonna M. E. Jääskeläinen, Jarmo Huopio, Hanna |
author_facet | Männistö, Jonna M. E. Jääskeläinen, Jarmo Huopio, Hanna |
author_sort | Männistö, Jonna M. E. |
collection | PubMed |
description | Background: Quality of life (QoL) has not been studied in patients with congenital hyperinsulinism (CHI). Objectives: To examine whether the health-related quality of life (HRQoL) is worsened in patients with persistent or transient CHI. Methods: We studied HRQoL of 65 children with CHI aged 3–17 years (60% males) recruited from the nationwide CHI registry. The median ages were 9.6 (range 3.5–16.3) and 7.4 (3.1–17.9) years in persistent (P-CHI, n = 33) and transient (T-CHI, n = 32) CHI groups, respectively. HRQoL was examined by generic KINDL-R questionnaire and the scores were compared to the age- and gender-specific reference values. Results: In self-reports of subjects aged 11–17 years and in parent reports of children aged 3–17 years, P-CHI or T-CHI children did not have statistically lower scores in any of the six dimensions (physical well-being, emotional well-being, self-esteem, family, friends, and school) or in total scores compared to the reference values. Conclusions: CHI is not associated with low HRQoL in childhood or adolescence. |
format | Online Article Text |
id | pubmed-6779698 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-67796982019-10-18 Health-Related Quality of Life in Children With Congenital Hyperinsulinism Männistö, Jonna M. E. Jääskeläinen, Jarmo Huopio, Hanna Front Endocrinol (Lausanne) Endocrinology Background: Quality of life (QoL) has not been studied in patients with congenital hyperinsulinism (CHI). Objectives: To examine whether the health-related quality of life (HRQoL) is worsened in patients with persistent or transient CHI. Methods: We studied HRQoL of 65 children with CHI aged 3–17 years (60% males) recruited from the nationwide CHI registry. The median ages were 9.6 (range 3.5–16.3) and 7.4 (3.1–17.9) years in persistent (P-CHI, n = 33) and transient (T-CHI, n = 32) CHI groups, respectively. HRQoL was examined by generic KINDL-R questionnaire and the scores were compared to the age- and gender-specific reference values. Results: In self-reports of subjects aged 11–17 years and in parent reports of children aged 3–17 years, P-CHI or T-CHI children did not have statistically lower scores in any of the six dimensions (physical well-being, emotional well-being, self-esteem, family, friends, and school) or in total scores compared to the reference values. Conclusions: CHI is not associated with low HRQoL in childhood or adolescence. Frontiers Media S.A. 2019-10-01 /pmc/articles/PMC6779698/ /pubmed/31632349 http://dx.doi.org/10.3389/fendo.2019.00670 Text en Copyright © 2019 Männistö, Jääskeläinen and Huopio. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Männistö, Jonna M. E. Jääskeläinen, Jarmo Huopio, Hanna Health-Related Quality of Life in Children With Congenital Hyperinsulinism |
title | Health-Related Quality of Life in Children With Congenital Hyperinsulinism |
title_full | Health-Related Quality of Life in Children With Congenital Hyperinsulinism |
title_fullStr | Health-Related Quality of Life in Children With Congenital Hyperinsulinism |
title_full_unstemmed | Health-Related Quality of Life in Children With Congenital Hyperinsulinism |
title_short | Health-Related Quality of Life in Children With Congenital Hyperinsulinism |
title_sort | health-related quality of life in children with congenital hyperinsulinism |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779698/ https://www.ncbi.nlm.nih.gov/pubmed/31632349 http://dx.doi.org/10.3389/fendo.2019.00670 |
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