c-Myc transactivates GP73 and promotes metastasis of hepatocellular carcinoma cells through GP73-mediated MMP-7 trafficking in a mildly hypoxic microenvironment

Golgi phosphoprotein 73 (GP73), encoded by GOLM1, is a highly expressed factor in hepatocellular carcinoma (HCC) cells and has been regarded for several years as a remarkable serum biomarker for the diagnosis of HCC. Recently, it was found that upregulation of GP73 promotes cancer metastasis, but th...

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Detalles Bibliográficos
Autores principales: Liu, Yiming, Zhou, Sining, Shi, Jieyao, Zhang, Xiaodi, Shentu, Linhui, Chen, Zhi, Zhou, Linfu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779757/
https://www.ncbi.nlm.nih.gov/pubmed/31591387
http://dx.doi.org/10.1038/s41389-019-0166-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779757/
https://www.ncbi.nlm.nih.gov/pubmed/31591387
http://dx.doi.org/10.1038/s41389-019-0166-7

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