The Dual Role of Kinin/Kinin Receptors System in Alzheimer’s Disease

Alzheimer’s disease (AD) is the most common neurodegenerative disease characterized by progressive spatial disorientation, learning and memory deficits, responsible for 60%–80% of all dementias. However, the pathological mechanism of AD remains unknown. Numerous studies revealed that kinin/kinin rec...

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Autores principales: Ji, Bingyuan, Wang, Qinqin, Xue, Qingjie, Li, Wenfu, Li, Xuezhi, Wu, Yili
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779775/
https://www.ncbi.nlm.nih.gov/pubmed/31632239
http://dx.doi.org/10.3389/fnmol.2019.00234
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author Ji, Bingyuan
Wang, Qinqin
Xue, Qingjie
Li, Wenfu
Li, Xuezhi
Wu, Yili
author_facet Ji, Bingyuan
Wang, Qinqin
Xue, Qingjie
Li, Wenfu
Li, Xuezhi
Wu, Yili
author_sort Ji, Bingyuan
collection PubMed
description Alzheimer’s disease (AD) is the most common neurodegenerative disease characterized by progressive spatial disorientation, learning and memory deficits, responsible for 60%–80% of all dementias. However, the pathological mechanism of AD remains unknown. Numerous studies revealed that kinin/kinin receptors system (KKS) may be involved in the pathophysiology of AD. In this review article, we summarized the roles of KKS in neuroinflammation, cerebrovascular impairment, tau phosphorylation, and amyloid β (Aβ) generation in AD. Moreover, we provide new insights into the mechanistic link between KKS and AD, and highlight the KKS as a potential therapeutic target for AD treatment.
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spelling pubmed-67797752019-10-18 The Dual Role of Kinin/Kinin Receptors System in Alzheimer’s Disease Ji, Bingyuan Wang, Qinqin Xue, Qingjie Li, Wenfu Li, Xuezhi Wu, Yili Front Mol Neurosci Neuroscience Alzheimer’s disease (AD) is the most common neurodegenerative disease characterized by progressive spatial disorientation, learning and memory deficits, responsible for 60%–80% of all dementias. However, the pathological mechanism of AD remains unknown. Numerous studies revealed that kinin/kinin receptors system (KKS) may be involved in the pathophysiology of AD. In this review article, we summarized the roles of KKS in neuroinflammation, cerebrovascular impairment, tau phosphorylation, and amyloid β (Aβ) generation in AD. Moreover, we provide new insights into the mechanistic link between KKS and AD, and highlight the KKS as a potential therapeutic target for AD treatment. Frontiers Media S.A. 2019-10-01 /pmc/articles/PMC6779775/ /pubmed/31632239 http://dx.doi.org/10.3389/fnmol.2019.00234 Text en Copyright © 2019 Ji, Wang, Xue, Li, Li and Wu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Ji, Bingyuan
Wang, Qinqin
Xue, Qingjie
Li, Wenfu
Li, Xuezhi
Wu, Yili
The Dual Role of Kinin/Kinin Receptors System in Alzheimer’s Disease
title The Dual Role of Kinin/Kinin Receptors System in Alzheimer’s Disease
title_full The Dual Role of Kinin/Kinin Receptors System in Alzheimer’s Disease
title_fullStr The Dual Role of Kinin/Kinin Receptors System in Alzheimer’s Disease
title_full_unstemmed The Dual Role of Kinin/Kinin Receptors System in Alzheimer’s Disease
title_short The Dual Role of Kinin/Kinin Receptors System in Alzheimer’s Disease
title_sort dual role of kinin/kinin receptors system in alzheimer’s disease
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779775/
https://www.ncbi.nlm.nih.gov/pubmed/31632239
http://dx.doi.org/10.3389/fnmol.2019.00234
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