Cargando…

Immune Cell-Type Specific Ablation of Adapter Protein ADAP Differentially Modulates EAE

The cytosolic adhesion and degranulation-promoting adapter protein ADAP is expressed in various hematopoietic cells including T cells, NK cells, myeloid cells, and platelets but absent in mature B cells. The role of ADAP in T cell activation, proliferation and integrin activation is well-accepted. W...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rudolph, Jochen, Meinke, Clara, Voss, Martin, Guttek, Karina, Kliche, Stefanie, Reinhold, Dirk, Schraven, Burkhart, Reinhold, Annegret
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779796/ https://www.ncbi.nlm.nih.gov/pubmed/31632410 http://dx.doi.org/10.3389/fimmu.2019.02343

Ejemplares similares

The Multiple Roles of the Cytosolic Adapter Proteins ADAP, SKAP1 and SKAP2 for TCR/CD3 -Mediated Signaling Events
por: Dadwal, Nirdosh, et al.
Publicado: (2021)

The adapter protein ADAP is required for selected dendritic cell functions
por: Togni, Mauro, et al.
Publicado: (2012)

Screening of FDA-Approved Drug Library Identifies Adefovir Dipivoxil as Highly Potent Inhibitor of T Cell Proliferation
por: Voss, Linda, et al.
Publicado: (2021)

Pitavastatin Is a Highly Potent Inhibitor of T-Cell Proliferation
por: Voss, Linda, et al.
Publicado: (2021)

Enhanced Susceptibility of ADAP-Deficient Mice to Listeria monocytogenes Infection Is Associated With an Altered Phagocyte Phenotype and Function
por: Böning, Martha A. L., et al.
Publicado: (2021)

ADAP Promotes Degranulation and Migration of NK Cells Primed During in vivo Listeria monocytogenes Infection in Mice
por: Böning, Martha A. L., et al.
Publicado: (2020)

Zinc Aspartate Induces IL-16 Secretion and Apoptosis in Human T Cells
por: Reinhold, Dirk, et al.
Publicado: (2021)

Adhesion and Degranulation Promoting Adapter Protein (ADAP) Is a Central Hub for Phosphotyrosine-Mediated Interactions in T Cells
por: Sylvester, Marc, et al.
Publicado: (2010)

Correction: Adhesion and Degranulation Promoting Adapter Protein (ADAP) Is a Central Hub for Phosphotyrosine-Mediated Interactions in T Cells
por: Sylvester, Marc, et al.
Publicado: (2010)

Selective targeting of transforming growth factor-beta1 into TCR/CD28 signalling plasma membrane domains silences T cell activation
por: Harder, Thomas, et al.
Publicado: (2014)

Allgemeine Kenntnisse zu häufig angewandten Testverfahren in der rheumatologisch-immunologischen Diagnostik und Forschung
por: Reinhold, Dirk, et al.
Publicado: (2023)

Filamin A Phosphorylation at Serine 2152 by the Serine/Threonine Kinase Ndr2 Controls TCR-Induced LFA-1 Activation in T Cells
por: Waldt, Natalie, et al.
Publicado: (2018)

Integrin Activation Through the Hematopoietic Adapter Molecule ADAP Regulates Dendritic Development of Hippocampal Neurons
por: Thiere, Marlen, et al.
Publicado: (2016)

Combined Treatment with Zinc Aspartate and Intravenous Immunoglobulins (IVIGs) Ameliorates Experimental Autoimmune Encephalomyelitis (EAE)
por: Straubel, Diana, et al.
Publicado: (2018)

miR-20a Inhibits TCR-Mediated Signaling and Cytokine Production in Human Naïve CD4(+) T Cells
por: Reddycherla, Amarendra V., et al.
Publicado: (2015)

Robust induction of neutralizing antibodies against the SARS‐CoV‐2 Delta variant after homologous Spikevax or heterologous Vaxzevria‐Spikevax vaccination
por: Hammerschmidt, Swantje I., et al.
Publicado: (2022)

Homologous and Heterologous Anti-COVID-19 Vaccination Does Not Induce New-Onset Formation of Autoantibodies Typically Accompanying Lupus Erythematodes, Rheumatoid Arthritis, Celiac Disease and Antiphospholipid Syndrome
por: Thurm, Christoph, et al.
Publicado: (2022)

Impact of Different JAK Inhibitors and Methotrexate on Lymphocyte Proliferation and DNA Damage
por: Reddig, Annika, et al.
Publicado: (2021)

Crucial role of SLP-76 and ADAP for neutrophil recruitment in mouse kidney ischemia-reperfusion injury
por: Block, Helena, et al.
Publicado: (2012)

The Fyn–ADAP Axis: Cytotoxicity Versus Cytokine Production in Killer Cells
por: Gerbec, Zachary J., et al.
Publicado: (2015)

Plasma concentrations of anti-inflammatory cytokine TGF-β are associated with hippocampal structure related to explicit memory performance in older adults
por: Raschick, Matthias, et al.
Publicado: (2023)

Ultrasensitive Antibody Detection by Agglutination-PCR (ADAP)
por: Tsai, Cheng-ting, et al.
Publicado: (2016)

IL‐13 determines specific IgE responses and SARS‐CoV‐2 immunity after mild COVID‐19 and novel mRNA vaccination
por: Meltendorf, Stefan, et al.
Publicado: (2022)

The Transmembrane Adaptor Protein SIT Inhibits TCR-Mediated Signaling
por: Arndt, Börge, et al.
Publicado: (2011)

Immunomodulation by memantine in therapy of Alzheimer's disease is mediated through inhibition of K(v)1.3 channels and T cell responsiveness
por: Lowinus, Theresa, et al.
Publicado: (2016)

Endogenous adaptation to low oxygen modulates T-cell regulatory pathways in EAE
por: Esen, Nilufer, et al.
Publicado: (2016)

Fyn‐binding protein ADAP supports actin organization in podocytes
por: Wu, Zhenzhen, et al.
Publicado: (2017)

Analysis of DNA Double-Strand Breaks and Cytotoxicity after 7 Tesla Magnetic Resonance Imaging of Isolated Human Lymphocytes
por: Reddig, Annika, et al.
Publicado: (2015)

PDK4 Inhibition Ameliorates Melatonin Therapy by Modulating Cerebral Metabolism and Remyelination in an EAE Demyelinating Mouse Model of Multiple Sclerosis
por: Ghareghani, Majid, et al.
Publicado: (2022)

Signaling Signatures and Functional Properties of Anti-Human CD28 Superagonistic Antibodies
por: Waibler, Zoe, et al.
Publicado: (2008)

Ongoing Oxidative Stress Causes Subclinical Neuronal Dysfunction in the Recovery Phase of EAE
por: Radbruch, Helena, et al.
Publicado: (2016)

Murine Cytomegalovirus Infection Induces Susceptibility to EAE in Resistant BALB/c Mice
por: Milovanovic, Jelena, et al.
Publicado: (2017)

Influence of Type I Interferons in Gammaherpesvirus-68 and Its Influence on EAE Enhancement
por: Márquez, Ana Citlali, et al.
Publicado: (2022)

Metabolic Interdependency of Th2 Cell-Mediated Type 2 Immunity and the Tumor Microenvironment
por: Schreiber, Simon, et al.
Publicado: (2021)

Obesity Promotes EAE Through IL-6 and CCL-2-Mediated T Cells Infiltration
por: Ji, Zhe, et al.
Publicado: (2019)

Editorial: Lymphocytes in MS and EAE: More Than Just a CD4(+) World
por: Rangachari, Manu, et al.
Publicado: (2017)

CD226 Attenuates Treg Proliferation via Akt and Erk Signaling in an EAE Model
por: Wang, Ning, et al.
Publicado: (2020)

ADAP2 Is an Interferon Stimulated Gene That Restricts RNA Virus Entry
por: Shu, Qian, et al.
Publicado: (2015)

Mice Heterozygous for the Sodium Channel Scn8a (Nav1.6) Have Reduced Inflammatory Responses During EAE and Following LPS Challenge
por: Alrashdi, Barakat, et al.
Publicado: (2021)

Extended Freeze-Dried BCG Instructed pDCs Induce Suppressive Tregs and Dampen EAE
por: Lippens, Carla, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_c1flh3or2545bj9uj2g0rgh7ck