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Altered Resting State Functional Activity and Microstructure of the White Matter in Migraine With Aura
Introduction: Brain structure and function were reported to be altered in migraine. Importantly our earlier results showed that white matter diffusion abnormalities and resting state functional activity were affected differently in the two subtypes of the disease, migraine with and without aura. Res...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779833/ https://www.ncbi.nlm.nih.gov/pubmed/31632336 http://dx.doi.org/10.3389/fneur.2019.01039 |
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author | Faragó, Péter Tóth, Eszter Kocsis, Krisztián Kincses, Bálint Veréb, Dániel Király, András Bozsik, Bence Tajti, János Párdutz, Árpád Szok, Délia Vécsei, László Szabó, Nikoletta Kincses, Zsigmond Tamás |
author_facet | Faragó, Péter Tóth, Eszter Kocsis, Krisztián Kincses, Bálint Veréb, Dániel Király, András Bozsik, Bence Tajti, János Párdutz, Árpád Szok, Délia Vécsei, László Szabó, Nikoletta Kincses, Zsigmond Tamás |
author_sort | Faragó, Péter |
collection | PubMed |
description | Introduction: Brain structure and function were reported to be altered in migraine. Importantly our earlier results showed that white matter diffusion abnormalities and resting state functional activity were affected differently in the two subtypes of the disease, migraine with and without aura. Resting fluctuation of the BOLD signal in the white matter was reported recently. The question arising whether the white matter activity, that is strongly coupled with gray matter activity is also perturbed differentially in the two subtypes of the disease and if so, is it related to the microstructural alterations of the white matter. Methods: Resting state fMRI, 60 directional DTI images and high-resolution T1 images were obtained from 51 migraine patients and 32 healthy volunteers. The images were pre-processed and the white matter was extracted. Independent component analysis was performed to obtain white matter functional networks. The differential expression of the white matter functional networks in the two subtypes of the disease was investigated with dual-regression approach. The Fourier spectrum of the resting fMRI fluctuations were compared between groups. Voxel-wise correlation was calculated between the resting state functional activity fluctuations and white matter microstructural measures. Results: Three white matter networks were identified that were expressed differently in migraine with and without aura. Migraineurs with aura showed increased functional connectivity and amplitude of BOLD fluctuation. Fractional anisotropy and radial diffusivity showed strong correlation with the expression of the frontal white matter network in patients with aura. Discussion: Our study is the first to describe changes in white matter resting state functional activity in migraine with aura, showing correlation with the underlying microstructure. Functional and structural differences between disease subtypes suggest at least partially different pathomechanism, which may necessitate handling of these subtypes as separate entities in further studies. |
format | Online Article Text |
id | pubmed-6779833 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-67798332019-10-18 Altered Resting State Functional Activity and Microstructure of the White Matter in Migraine With Aura Faragó, Péter Tóth, Eszter Kocsis, Krisztián Kincses, Bálint Veréb, Dániel Király, András Bozsik, Bence Tajti, János Párdutz, Árpád Szok, Délia Vécsei, László Szabó, Nikoletta Kincses, Zsigmond Tamás Front Neurol Neurology Introduction: Brain structure and function were reported to be altered in migraine. Importantly our earlier results showed that white matter diffusion abnormalities and resting state functional activity were affected differently in the two subtypes of the disease, migraine with and without aura. Resting fluctuation of the BOLD signal in the white matter was reported recently. The question arising whether the white matter activity, that is strongly coupled with gray matter activity is also perturbed differentially in the two subtypes of the disease and if so, is it related to the microstructural alterations of the white matter. Methods: Resting state fMRI, 60 directional DTI images and high-resolution T1 images were obtained from 51 migraine patients and 32 healthy volunteers. The images were pre-processed and the white matter was extracted. Independent component analysis was performed to obtain white matter functional networks. The differential expression of the white matter functional networks in the two subtypes of the disease was investigated with dual-regression approach. The Fourier spectrum of the resting fMRI fluctuations were compared between groups. Voxel-wise correlation was calculated between the resting state functional activity fluctuations and white matter microstructural measures. Results: Three white matter networks were identified that were expressed differently in migraine with and without aura. Migraineurs with aura showed increased functional connectivity and amplitude of BOLD fluctuation. Fractional anisotropy and radial diffusivity showed strong correlation with the expression of the frontal white matter network in patients with aura. Discussion: Our study is the first to describe changes in white matter resting state functional activity in migraine with aura, showing correlation with the underlying microstructure. Functional and structural differences between disease subtypes suggest at least partially different pathomechanism, which may necessitate handling of these subtypes as separate entities in further studies. Frontiers Media S.A. 2019-10-01 /pmc/articles/PMC6779833/ /pubmed/31632336 http://dx.doi.org/10.3389/fneur.2019.01039 Text en Copyright © 2019 Faragó, Tóth, Kocsis, Kincses, Veréb, Király, Bozsik, Tajti, Párdutz, Szok, Vécsei, Szabó and Kincses. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neurology Faragó, Péter Tóth, Eszter Kocsis, Krisztián Kincses, Bálint Veréb, Dániel Király, András Bozsik, Bence Tajti, János Párdutz, Árpád Szok, Délia Vécsei, László Szabó, Nikoletta Kincses, Zsigmond Tamás Altered Resting State Functional Activity and Microstructure of the White Matter in Migraine With Aura |
title | Altered Resting State Functional Activity and Microstructure of the White Matter in Migraine With Aura |
title_full | Altered Resting State Functional Activity and Microstructure of the White Matter in Migraine With Aura |
title_fullStr | Altered Resting State Functional Activity and Microstructure of the White Matter in Migraine With Aura |
title_full_unstemmed | Altered Resting State Functional Activity and Microstructure of the White Matter in Migraine With Aura |
title_short | Altered Resting State Functional Activity and Microstructure of the White Matter in Migraine With Aura |
title_sort | altered resting state functional activity and microstructure of the white matter in migraine with aura |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779833/ https://www.ncbi.nlm.nih.gov/pubmed/31632336 http://dx.doi.org/10.3389/fneur.2019.01039 |
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