Cargando…

Association of SGK1 Polymorphisms With Susceptibility to Coronary Heart Disease in Chinese Han Patients With Comorbid Depression

There is a strong link between heart disease and depression, both of which are closely related to lifetime stress exposure. Serum/glucocorticoid-regulated kinase 1 (SGK1) is a stress-responsive gene with a pivotal role in both the heart and brain. To determine the role of SGK1 polymorphisms (rs27581...

Descripción completa

Detalles Bibliográficos
Autores principales: Han, Wenxiu, Zhang, Haixia, Gong, Xiaoxue, Guo, Yujin, Yang, Mengqi, Zhang, Hailiang, Zhou, Xueyuan, Li, Gongying, Liu, Yuanyuan, Jiang, Pei, Yan, Genquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779850/
https://www.ncbi.nlm.nih.gov/pubmed/31632443
http://dx.doi.org/10.3389/fgene.2019.00921
_version_ 1783456986465042432
author Han, Wenxiu
Zhang, Haixia
Gong, Xiaoxue
Guo, Yujin
Yang, Mengqi
Zhang, Hailiang
Zhou, Xueyuan
Li, Gongying
Liu, Yuanyuan
Jiang, Pei
Yan, Genquan
author_facet Han, Wenxiu
Zhang, Haixia
Gong, Xiaoxue
Guo, Yujin
Yang, Mengqi
Zhang, Hailiang
Zhou, Xueyuan
Li, Gongying
Liu, Yuanyuan
Jiang, Pei
Yan, Genquan
author_sort Han, Wenxiu
collection PubMed
description There is a strong link between heart disease and depression, both of which are closely related to lifetime stress exposure. Serum/glucocorticoid-regulated kinase 1 (SGK1) is a stress-responsive gene with a pivotal role in both the heart and brain. To determine the role of SGK1 polymorphisms (rs2758151, rs1743963, rs9493857, rs1763509, rs9376026, and rs9389154) in susceptibility to comorbid coronary heart disease (CHD) and depression, we conducted a hospital-based case–control study involving 257 CHD cases (including 69 cases with depression and 188 cases without depression) and 107 controls in a Chinese Han population. Six single-nucleotide polymorphisms (SNPs) in the SGK1 gene were successfully genotyped by polymerase chain reaction–ligase detection reaction (PCR-LDR) assay. Our results showed no significant differences in SGK1 genetic polymorphisms between CHD patients and controls, whereas significant associations were observed between SGK1 SNPs (rs1743963 and rs1763509) and the development of depression in CHD patients (P = 0.018 by genotype, P = 0.032 by allele; P = 0.017 by genotype, P = 0.003 by allele, respectively). However, none of these associations remained significant after Bonferroni correction (P = 0.054 for rs1743963; P = 0.051 for rs1763509). Interestingly, both the GG genotype of SGK1 rs1743963 and AA genotype of SGK1 rs1763509 were associated with a higher risk of depression in CHD patients; for rs1763509, the Patient Health Questionnaire-9 (PHQ-9) scores in the carriers of the risk genotype for comorbid depression, AA, were significantly higher than in GG and AG carriers (P = 0.008). Notably, haplotype analysis indicated that haplotype GGA significantly increased the risk of depression in CHD patients (P = 0.011, odds ratio (OR) = 1.717, 95% confidence interval (CI) = 1.132–2.605), whereas haplotype AAG may be a protective factor for CHD patients with comorbid depression (P = 0.038, OR = 0.546, 95% CI = 0.307–0.972). It should be noted that only the significance of haplotype GGA survived after Bonferroni adjustment (P = 0.044) and that no significant differences were found for other SGK1 SNPs (rs2758151, rs9493857, rs9376026, and rs9389154) between CHD patients with and without depression. These findings, for the first time, elucidate the important role of SGK1 variants in the comorbidity of CHD and depression.
format Online
Article
Text
id pubmed-6779850
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-67798502019-10-18 Association of SGK1 Polymorphisms With Susceptibility to Coronary Heart Disease in Chinese Han Patients With Comorbid Depression Han, Wenxiu Zhang, Haixia Gong, Xiaoxue Guo, Yujin Yang, Mengqi Zhang, Hailiang Zhou, Xueyuan Li, Gongying Liu, Yuanyuan Jiang, Pei Yan, Genquan Front Genet Genetics There is a strong link between heart disease and depression, both of which are closely related to lifetime stress exposure. Serum/glucocorticoid-regulated kinase 1 (SGK1) is a stress-responsive gene with a pivotal role in both the heart and brain. To determine the role of SGK1 polymorphisms (rs2758151, rs1743963, rs9493857, rs1763509, rs9376026, and rs9389154) in susceptibility to comorbid coronary heart disease (CHD) and depression, we conducted a hospital-based case–control study involving 257 CHD cases (including 69 cases with depression and 188 cases without depression) and 107 controls in a Chinese Han population. Six single-nucleotide polymorphisms (SNPs) in the SGK1 gene were successfully genotyped by polymerase chain reaction–ligase detection reaction (PCR-LDR) assay. Our results showed no significant differences in SGK1 genetic polymorphisms between CHD patients and controls, whereas significant associations were observed between SGK1 SNPs (rs1743963 and rs1763509) and the development of depression in CHD patients (P = 0.018 by genotype, P = 0.032 by allele; P = 0.017 by genotype, P = 0.003 by allele, respectively). However, none of these associations remained significant after Bonferroni correction (P = 0.054 for rs1743963; P = 0.051 for rs1763509). Interestingly, both the GG genotype of SGK1 rs1743963 and AA genotype of SGK1 rs1763509 were associated with a higher risk of depression in CHD patients; for rs1763509, the Patient Health Questionnaire-9 (PHQ-9) scores in the carriers of the risk genotype for comorbid depression, AA, were significantly higher than in GG and AG carriers (P = 0.008). Notably, haplotype analysis indicated that haplotype GGA significantly increased the risk of depression in CHD patients (P = 0.011, odds ratio (OR) = 1.717, 95% confidence interval (CI) = 1.132–2.605), whereas haplotype AAG may be a protective factor for CHD patients with comorbid depression (P = 0.038, OR = 0.546, 95% CI = 0.307–0.972). It should be noted that only the significance of haplotype GGA survived after Bonferroni adjustment (P = 0.044) and that no significant differences were found for other SGK1 SNPs (rs2758151, rs9493857, rs9376026, and rs9389154) between CHD patients with and without depression. These findings, for the first time, elucidate the important role of SGK1 variants in the comorbidity of CHD and depression. Frontiers Media S.A. 2019-10-01 /pmc/articles/PMC6779850/ /pubmed/31632443 http://dx.doi.org/10.3389/fgene.2019.00921 Text en Copyright © 2019 Han, Zhang, Gong, Guo, Yang, Zhang, Zhou, Li, Liu, Jiang and Yan http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Han, Wenxiu
Zhang, Haixia
Gong, Xiaoxue
Guo, Yujin
Yang, Mengqi
Zhang, Hailiang
Zhou, Xueyuan
Li, Gongying
Liu, Yuanyuan
Jiang, Pei
Yan, Genquan
Association of SGK1 Polymorphisms With Susceptibility to Coronary Heart Disease in Chinese Han Patients With Comorbid Depression
title Association of SGK1 Polymorphisms With Susceptibility to Coronary Heart Disease in Chinese Han Patients With Comorbid Depression
title_full Association of SGK1 Polymorphisms With Susceptibility to Coronary Heart Disease in Chinese Han Patients With Comorbid Depression
title_fullStr Association of SGK1 Polymorphisms With Susceptibility to Coronary Heart Disease in Chinese Han Patients With Comorbid Depression
title_full_unstemmed Association of SGK1 Polymorphisms With Susceptibility to Coronary Heart Disease in Chinese Han Patients With Comorbid Depression
title_short Association of SGK1 Polymorphisms With Susceptibility to Coronary Heart Disease in Chinese Han Patients With Comorbid Depression
title_sort association of sgk1 polymorphisms with susceptibility to coronary heart disease in chinese han patients with comorbid depression
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779850/
https://www.ncbi.nlm.nih.gov/pubmed/31632443
http://dx.doi.org/10.3389/fgene.2019.00921
work_keys_str_mv AT hanwenxiu associationofsgk1polymorphismswithsusceptibilitytocoronaryheartdiseaseinchinesehanpatientswithcomorbiddepression
AT zhanghaixia associationofsgk1polymorphismswithsusceptibilitytocoronaryheartdiseaseinchinesehanpatientswithcomorbiddepression
AT gongxiaoxue associationofsgk1polymorphismswithsusceptibilitytocoronaryheartdiseaseinchinesehanpatientswithcomorbiddepression
AT guoyujin associationofsgk1polymorphismswithsusceptibilitytocoronaryheartdiseaseinchinesehanpatientswithcomorbiddepression
AT yangmengqi associationofsgk1polymorphismswithsusceptibilitytocoronaryheartdiseaseinchinesehanpatientswithcomorbiddepression
AT zhanghailiang associationofsgk1polymorphismswithsusceptibilitytocoronaryheartdiseaseinchinesehanpatientswithcomorbiddepression
AT zhouxueyuan associationofsgk1polymorphismswithsusceptibilitytocoronaryheartdiseaseinchinesehanpatientswithcomorbiddepression
AT ligongying associationofsgk1polymorphismswithsusceptibilitytocoronaryheartdiseaseinchinesehanpatientswithcomorbiddepression
AT liuyuanyuan associationofsgk1polymorphismswithsusceptibilitytocoronaryheartdiseaseinchinesehanpatientswithcomorbiddepression
AT jiangpei associationofsgk1polymorphismswithsusceptibilitytocoronaryheartdiseaseinchinesehanpatientswithcomorbiddepression
AT yangenquan associationofsgk1polymorphismswithsusceptibilitytocoronaryheartdiseaseinchinesehanpatientswithcomorbiddepression